Reading...
Play button
Play button
Use LEFT and RIGHT arrow keys to navigate between flashcards;
Use UP and DOWN arrow keys to flip the card;
H to show hint;
A reads text to speech;
13 Cards in this Set
- Front
- Back
|
Nitroglycerin
Early Hospital Care Anti-Ischemic Therapy |
MOA:
- Dilates coronary vessels - reduce SVR & preload - metabolized NO is released -> stimulates guanylyl cyclase -> increase cGMP -> Dephosphorylate MLC -> SM relaxation & vasodilation PK: - well absorbed from buccal mucosa, intestine, skin, and aveoli - sublingual, oral, or IV - rapid onset (few mins) - short duration (15-30 mins) Caution: - hypotension - RV infarction or severe aortic stenosis CI: - phosphodiesterase inhibitor last 24 hrs |
|
|
Metoprolol
Atenolol Early Hospital Care Anti-Ischemic Therapy |
Beta blockers
CI: - active bronchospasms - severe bradycardia - heart block > 1st degree - pul edema - hypotension - cocaine |
|
|
Atorvastatin
Early Hospital Care Anti-Ischemic Therapy |
Statin
|
|
|
Aspirin
Early Hospital Care Anti-Ischemic Therapy |
COX irreversible inhibitor -l PGI2 & TXA2
- Small doses 75-100mg inhibit TXA2 - crushed/chewed rapid - continued for secondary prevention SE: Peptic ulcer bleeding in patients >60 yrs |
|
|
Clopidogrel
Early Hospital Care Anti-Ischemic Therapy |
Irreversible inhibitor P2Y12 receptor (ADP)
thienopyridine SE: Bleeding, dyspepsia, rashes |
|
|
Prasugrel
Early Hospital Care Anti-Ischemic Therapy |
Irreversible inhibitor P2Y12 receptor (ADP)
thienopyridine > Clopidogrel CI: - prior TIA/Stroke - patients >75 yrs |
|
|
Ticagrelor
Early Hospital Care Anti-Ischemic Therapy |
Reversible inhibitor P2Y12 receptor (ADP)
Cyclopentyltriazolopyrimidines > Clopidogrel |
|
|
Ticlopidine
Early Hospital Care Anti-Ischemic Therapy |
P2Y12 (ADP) inhibitor
|
|
|
Eptifibatide
Abciximab Tirofiban Early Hospital Care Anti-Ischemic Therapy |
GIIbIIIa inhibitors
Before angiography: Epitifibatide After diagnostic angiography: Eptifibatide Abciximab |
|
|
Unfractionated Heparin
Enoxaparin Fondaparinux Bivalirubin (direct) Early Hospital Care Anticoagulant Therapy |
Thrombin inhibitors via antithrombin 3
Early invasive Bivalirubin Unfractionated Heparin Conservative (non-invasive) Enoxaparin Fondaparinux |
|
|
Fibrinolytics
|
Alteplase (tPA) = Reteplase (rPA) = Tenecteplase (TNK-tPA) but lower rates of noncerebral bleeding events & easier to use
|
|
|
Ranolazine
|
Chronic stable angina
500mg twice/day Symptomatic – 1000mg twice/day CI: QT prolongation Hepatic disease Potent inhibitors of CYP 3A4 - Diltiazem - Verapamil Inhibits metabolism - Digoxin - Simvastatin |
|
|
Cardiac X Syndrome
|
Angina-like chest pain with exertion, normal coronary arteries
Benign B-blocks decrease frequency & severity of symptoms Nitroglycerin Ca channel blockers not very effective |
