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50 Cards in this Set

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3 types of anti-cholinesterases
1) Edrophonium
2) Neostigmine (carbamates)
3) Organophosphates
Edrophonium
Shortest acting anticholinesterase (minutes)

Diagnose Myesthenia Gravis
Neostigmine
Anticholinesterase
- Blocks Achase for house (kind of long acting)
aka Carbamate
Carbamate
Anticholinesterase
- Blocks Achase for houre (kind of long acting)
aka Neostigmine
Organophosphate
Anticholinesterase
- Irreversible (longest acting)
- Toxicity
Acetylcholinase Regenerator
Pralidoxime
In a normal, resting person, what is the effect of a ___ blocker will be to decrease ___ effects
nicotinic, parasympathetic (since normal resting person experiences more parasympathetic stimulation)
atropine
Anti-muscarinic
Hemicholinium
Ach inhibitor: inhibits transport of choline into nerve terminal
Vesamicol
Inhibits active transport of Ach into vesicles
Botulinum Toxin
Inhibits Ach release
Metyrosine
NE inhibitior; inhibits tyrosine hydroxilase
Reserpine
NE inhibitor; inhibits transport of NE and DA into vesicles
Guanethidine
Inhibits release of NE and dopamine
Presynaptic Ach inhibitors
Hemicholinium
Vesamicol
Botulinum Toxin
Presynaptic NE inhibitors
Metyrosine
Reserpine
Guanethedine
Inhibition of NE and DA reuptake
Cocaine and TCA (tricyclic antidepressants)
Outside of cleft, these metabolize DA and NE
MAO and COMT
Epinepherine
Sympathomimetic
Effects at all receptor subtypes (alpha and beta).
Small doses: more beta effects.
Large doses produce more alpha effects (increased BP, PP, HR)
Norepinepherine
Effects at a1, a2, b1.
Increased BP, *Lower* HR (from reflex bradycardia)
Phenyleprhrine
Alpha-1 agonist
Contracts vascular sm muscle, dilates pupil, erects hair

Tox: Reflex bradycardia, hypertension
Clonodine
Alpha-2 agonist

Reduces sypmathetic outflow and blood pressure

Tox: salt retention
Sudden discontinuation leads to rebound hypertension
A drug who's discontinuation leads to rebound hypertension
Clonodine (a2 agonist)
Isoproterenol
Non-selective beta agonist

Increases HR, contractility
Tox: Arrythmias, tachycardia
Dobutamine
beta-1 agonist

Increases HR, contractility, renin release
Tox: Arrythmias, tachycardia
Terbutaline
B2 agonist

Treat asthma
Tox: skeletal muscle tremor
Salmeterol
B2 agonist

Treat asthma
Tox: skeletal muscle tremor
Albeuterol
B2 agonist

Treat asthma
Tox: skeletal muscle tremor
Two types of indirect acting sympathomimetics
1) Reuptake inhibitors (Cocaine, TCA)
2) Releasers (amphetamine, tyramine)

Non-selective!!!
Cocaine
Catecholamine reuptake inhibitor
TCA
Catecholamine reuptake inhibitor
Amphetamine
Catecholamine releaser (MAO resistant)
Tyramine
Catecholamine releaser (metabolized by MAO except when administered with MAOi)
Signs of cholinergic excess
DUMBBELSS
Bradykinin - what does it do?
Vasodilator
Quinidine
Class I AA: Blocks fast inward Na current
Quinidine
Blocker of fast inward Na current
Cevelimine
Direct acting Muscarininc agonist
Tx: Sjogren's Syndrome
Bethanechol
Direct acting Muscarininc agonist

No CNS effects
Carbachol
Direct acting Muscarininc agonist

No CNS effects
Muscarine
Direct acting Muscarininc agonist
Toxic
Pilocarpine
Direct acting Muscarininc agonist

Tx: Glaucoma
Propranolol
Nonselective beta blocker
Atenolol
B1 antagonist
Phenoxybenzamine
Nonselective alpha blocker
Phentolamine
Nonselective alpha blocker
Prazosin
A1 blocker
Timolol
Nonselective beta blocker
Tx: Glaucoma
Tubocurarine
Anti-nicotinic (muscle relaxation during surgery or intubation)
Tx for Organophosphate poisoning
Atropine and pralidoxime (Achase regenerator)