Cv Drugs

Front 1

3 types of anti-cholinesterases

Back 1

1) Edrophonium
2) Neostigmine (carbamates)
3) Organophosphates

Front 2

Edrophonium

Back 2

Shortest acting anticholinesterase (minutes)

Diagnose Myesthenia Gravis

Front 3

Neostigmine

Back 3

Anticholinesterase
- Blocks Achase for house (kind of long acting)
aka Carbamate

Front 4

Carbamate

Back 4

Anticholinesterase
- Blocks Achase for houre (kind of long acting)
aka Neostigmine

Front 5

Organophosphate

Back 5

Anticholinesterase
- Irreversible (longest acting)
- Toxicity

Front 6

Acetylcholinase Regenerator

Back 6

Pralidoxime

Front 7

In a normal, resting person, what is the effect of a ___ blocker will be to decrease ___ effects

Back 7

nicotinic, parasympathetic (since normal resting person experiences more parasympathetic stimulation)

Front 8

atropine

Back 8

Anti-muscarinic

Front 9

Hemicholinium

Back 9

Ach inhibitor: inhibits transport of choline into nerve terminal

Front 10

Vesamicol

Back 10

Inhibits active transport of Ach into vesicles

Front 11

Botulinum Toxin

Back 11

Inhibits Ach release

Front 12

Metyrosine

Back 12

NE inhibitior; inhibits tyrosine hydroxilase

Front 13

Reserpine

Back 13

NE inhibitor; inhibits transport of NE and DA into vesicles

Front 14

Guanethidine

Back 14

Inhibits release of NE and dopamine

Front 15

Presynaptic Ach inhibitors

Back 15

Hemicholinium
Vesamicol
Botulinum Toxin

Front 16

Presynaptic NE inhibitors

Back 16

Metyrosine
Reserpine
Guanethedine

Front 17

Inhibition of NE and DA reuptake

Back 17

Cocaine and TCA (tricyclic antidepressants)

Front 18

Outside of cleft, these metabolize DA and NE

Back 18

MAO and COMT

Front 19

Epinepherine

Back 19

Sympathomimetic
Effects at all receptor subtypes (alpha and beta).
Small doses: more beta effects.
Large doses produce more alpha effects (increased BP, PP, HR)

Front 20

Norepinepherine

Back 20

Effects at a1, a2, b1.
Increased BP, *Lower* HR (from reflex bradycardia)

Front 21

Phenyleprhrine

Back 21

Alpha-1 agonist
Contracts vascular sm muscle, dilates pupil, erects hair

Tox: Reflex bradycardia, hypertension

Front 22

Clonodine

Back 22

Alpha-2 agonist

Reduces sypmathetic outflow and blood pressure

Tox: salt retention
Sudden discontinuation leads to rebound hypertension

Front 23

A drug who's discontinuation leads to rebound hypertension

Back 23

Clonodine (a2 agonist)

Front 24

Isoproterenol

Back 24

Non-selective beta agonist

Increases HR, contractility
Tox: Arrythmias, tachycardia

Front 25

Dobutamine

Back 25

beta-1 agonist

Increases HR, contractility, renin release
Tox: Arrythmias, tachycardia

Front 26

Terbutaline

Back 26

B2 agonist

Treat asthma
Tox: skeletal muscle tremor

Front 27

Salmeterol

Back 27

B2 agonist

Treat asthma
Tox: skeletal muscle tremor

Front 28

Albeuterol

Back 28

B2 agonist

Treat asthma
Tox: skeletal muscle tremor

Front 29

Two types of indirect acting sympathomimetics

Back 29

1) Reuptake inhibitors (Cocaine, TCA)
2) Releasers (amphetamine, tyramine)

Non-selective!!!

Front 30

Cocaine

Back 30

Catecholamine reuptake inhibitor

Front 31

TCA

Back 31

Catecholamine reuptake inhibitor

Front 32

Amphetamine

Back 32

Catecholamine releaser (MAO resistant)

Front 33

Tyramine

Back 33

Catecholamine releaser (metabolized by MAO except when administered with MAOi)

Front 34

Signs of cholinergic excess

Back 34

DUMBBELSS

Front 35

Bradykinin - what does it do?

Back 35

Vasodilator

Front 36

Quinidine

Back 36

Class I AA: Blocks fast inward Na current

Front 37

Quinidine

Back 37

Blocker of fast inward Na current

Front 38

Cevelimine

Back 38

Direct acting Muscarininc agonist
Tx: Sjogren's Syndrome

Front 39

Bethanechol

Back 39

Direct acting Muscarininc agonist

No CNS effects

Front 40

Carbachol

Back 40

Direct acting Muscarininc agonist

No CNS effects

Front 41

Muscarine

Back 41

Direct acting Muscarininc agonist
Toxic

Front 42

Pilocarpine

Back 42

Direct acting Muscarininc agonist

Tx: Glaucoma

Front 43

Propranolol

Back 43

Nonselective beta blocker

Front 44

Atenolol

Back 44

B1 antagonist

Front 45

Phenoxybenzamine

Back 45

Nonselective alpha blocker

Front 46

Phentolamine

Back 46

Nonselective alpha blocker

Front 47

Prazosin

Back 47

A1 blocker

Front 48

Timolol

Back 48

Nonselective beta blocker
Tx: Glaucoma

Front 49

Tubocurarine

Back 49

Anti-nicotinic (muscle relaxation during surgery or intubation)

Front 50

Tx for Organophosphate poisoning

Back 50

Atropine and pralidoxime (Achase regenerator)