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18 Cards in this Set
- Front
- Back
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Expected results in focal segmental glomerulosclerosis |
An area of collagenous sclerosis Some (focal) glomeruli are affected and just part of the affected glomerulus is involved (segmental) with the sclerosis. |
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Comparison of FSGS and MCD |
FSGS are more likely to have non-selective proteinuria, hematuria, progression to chronic renal failure, and poor response to corticosteroid therapy. |
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Membranous GN |
Diffuse thickening of capillary walls but the cellularity is not increased. Could be linked to chronic infectious disease - hep. B or SLE IgG and complement deposits in BM |
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When are crescents seen? |
Rapidly progressive glomerulonephritis Proliferating epithelial cells. RPGN is a description, not a specific disease. |
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Genes and proteins in ADPKD |
PKD1PKD2 Polycystin |
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Position of cysts in ADPKD and ARPKD |
Dominant - whole nephron Recessive - collecting duct |
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What does eosin stain? |
Pink - basic cytoplasm |
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Haematoxylin |
Purple - acidic nuclei, RNA in cytoplasm |
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Shape of PT cells |
columnar and have pronounced brush-borders(their apical surface is uneven).
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Shape of DT cells |
cuboidal,smaller, contain less cytoplasm, lack a brush border and their nuclei are morepronounced.
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Cause of rapidly progressive crescentic glomerulonephritis |
streptococcal infection, systemic lupus, vasculitis, Goodpasture's syndrome, idiopathic. |
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Chronic glomerulonephritis |
end stage kidney hyalinization (hyalinosclerosis - total replacement of glomeruli and Bowmann's space with hyaline) he hyaline is an amorphous material, pink, homogenous, resulted from combination of plasma proteins, increased mesangial matrix and collagen. |
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Name all primary glomerulophiritis |
acute diffuse proliferative glomerulonephritis (nephritic syndrome) rapidly progressive (crescentic) glomerulonephritis lipoid nephrosis (minimal change disease) (nephrotic syndrome) membranous glomerulonephritis (membranous nephropathy) (nephrotic syndrome) membranoproliferative glomerulonephritis (nephrotic syndrome) focal segmental glomerulosclerosis (nephrotic syndrome) IgA nephropathy (Berger's disease) chronic glomerulonephritis |
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Name all secondary glomerulophiritis |
SLE, DM, Goodpasture's |
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What is sclerosis?
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Abnormal hardening |
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Membranoproliferative glomerulonephritis |
Mesangial cell proliferation Increased mesangial matrix Influx of leukocytes Swelling of cells lining peripheral capillaries |
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Where is IgA deposited? |
Mesangial region |
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Chronic glomuerlonephritis |
Replacement of glomeruli by collagen |
