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21 Cards in this Set
- Front
- Back
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intermediate filaments
What is the cell type for CYTOKERATINS? |
Cell type: epithelium
examples: keratinizing and nonkeratinizing epithelia |
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intermediate filaments
What is the cell type for VIMENTIN filaments? |
cell type: MESENCHYMAL CELLS
examples: fibroblasts, chondroblasts, macrophages, endothelial cells, vascular smooth muscle |
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intermediate filaments
What is the cell type for DESMIN filaments? |
cell type: MUSCLE
examples:striated and smooth muscle (except vascular smooth muscle) |
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intermediate filaments
What is the cell type for GILIAL FIBRILLARY ACIDIC PROTEINS filaments? |
cell type: GLIAL CELLS
examples:Astrocytes |
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intermediate filaments
What is the cell type for NEUROFILAMENTS |
cell type: NEURONS
examples: most neurons |
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Chemical disruptor of microtubules
Colchicine |
prevents polymerization
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Chemical disruptor of microtubules
Vinblastine |
prevents polymerization
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Chemical disruptor of microtubules
Taxol |
stabilities MT, preventing depolymerization
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diameter ACTIN
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6-7 nm
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diameter MICROTUBULES
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24 nm
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diameter INTERMEDIATE FILAMENTS
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10 nm
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function MICROTUBULES
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vesicular transport, cell elongation/shape, moment of chromosomes, movement of cells
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function ACTIN
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anchor membranes, from terminal webs and microvilli cores, form lamellipodia/filipodia, movement; contractile elements and contractile rings in cytokinesis
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needed for MICROTUBULE GROWTH
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GTP + ionic enviroment
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needed for ACTIN POLYMERIZATION
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ATP, K+, Mg2+
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disruptors of actin
CYTOCHALASIN B&D |
prevent polymerization
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disruptors of actin
PHALLOIDIN |
prevent depolymerization
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intermediate filaments
Where are LAMINS found? |
nuclear envelope of all cells
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Structure
MICROTUBULES |
13 dimers of alpha- and beta tubulin; polarized, originating at MTOC, + end in periphery
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Structure
ACTIN |
G-actin (globular) polymerize to form F-actin (filamentous); polarized
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Structure
INTERMEDIATE FILAMENTS |
8 staggered tetramers, each composed of 2 coiled dimers; conserved alpha helix center with different ends; not polarized but antiparallel
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