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209 Cards in this Set

  • Front
  • Back
Any drug approved for prescription will be found in the ______
National Formulary
Pregnant women used a medication that was effective for the women but harmful to the fetus, in response to this FDA tightened control over investigational drugs and pregnancy safety categories developed under all under which amendment?
Kefauver-Harris Amendment
Prescription and OTC drugs must follow the standards found in this publication.
The US Pharmacopeia
A drug company claimed their antidepressant drug will also help you lose 30 lbs in a month, which isn't true. The company is violating which amendment?
Sherley Amendment
A person is studying the effects of chemical substances on living tissues. This person is studying _____
pharmacology
An elderly women is now able to afford her medications under this act
Medicare Prescription Drug Improvement and Modernization Act
(Medicare Part D)
This amendment distinguished between prescription (legend) and OTC drugs. It also allowed only licensed pharmacist to dispense prescription drugs.
Durham- Humphrey Amendment
A man in China attempts to send opium, cocaine and substances containing their derivatives to the US. He is prevented from doing so because of what act?
The Harrison Narcotic Act; it also defined the legal term narcotic
Chemical substances classified as drugs can be derived from _______
organic compounds, such as plants or animals, and inorganic compounds, such as minerals.
Heroin is a schedule 1 drug, which are considered the most dangerous and illegal. the development of "schedule" categories and programs to prevent and treat drug abuse was established in this act ____
The Comprehensive Drug Abuse Prevention and Control Act
Health care insurance coverage is more accessible and affordable under this act
Comprehensive Health Care Reform Act
A pharmaceutical company is developing a drug to treat the rare Addison's disease. This company will receive a tax credit under which act?
The Orphan Drug Act
Some drugs are formulated through ___________
genetic engineering or are synthetically produced
A drug company wants to begin marketing a new drug, what type of application must they submit and to whom?
Investigational New Drug (IND) application to the FDA
A patient wants to review her medical records and the health facility must allow her to under this act
Health Insurance Portability and Accountability Act
Workers and their families are allowed to maintain their health insurance coverage after job lost, at their own expense under this act
The Consolidated Omnibus Budget Reconciliation Act (COBRA)
Which agency of the U.S. Department of Health and Human Services regulates drugs in the U.S.?
The Food and Drug Administration (FDA)
Drug companies must submit IND and conduct toxicity test in lab animals before marketing new drugs under what act?
Federal Food, Drug and Cosmetic Act
A drug is recalled from pharmacies and a new drug is approved, who is empowered to make these decisions?
FDA
I bought a bottle of cold medicine and it was wrapped in thick plastic and i couldnt open the lid, i can thank which requirement for this?
The Tamper Proof Packaging Requirement
Claritin is the trade name for Loratadine. Claritin's patent expired in 2002 and other companies were able to market loratadine under other trade names because of this law
The Generic Drug Law
Plan B was a medication that required a prescription, now it is available over the counter. Who is responsible for determining this drug can change from prescription status to OTC?
FDA
A patient receives a prescription for a controlled substance, there are no refills on this prescription because of what amendment?
Durham- Humphrey Amendment
A company is developing a drug to prevent AIDS, a major public threat, the review process will be accelerated under this act
The Drug Relations Act
In the early 1900s, a man was arrested for selling a bottle of salt water labeled antibiotics. Which act allowed for this man to be arrested?
The Federal Food and Drug Act
Certain drugs must be tested for safety and effectiveness in children under this act
The Pediatric Research Equality Act
Pre-clinical trials done by pharmaceutical companies are done in/on _______-
test tubes and animals
Pharmaceutical companies must demonstrate that a new drug has some advantage over __________
similar drugs already on the market
When lab studies are completed, the info must be submitted to ___________
FDA
To begin testing on humans, the company must be granted an ________--
investigational new drug exemption
A company gives a small number of healthy volunteers and the biological effects of the drug in humans and dosage ranges are determined. This takes place in which phase of the clinical trials?
Phase 1
A company gives a small number number of volunteers who have the disorder the drug is intended to treat. Data is gathered on the drug's efficacy and adverse effects. This takes place in which phase of the clinical trials?
Phase 2
A pharmaceutical company prescribes an investigational drug to a large number of patients who has the disorder the drug is intended to treat. This takes place in which phase of clinical trials?
Phase 3
In what phase of clinical trials does the company submit a new drug application (NDA) ?
Phase 3
Once a new drug enters the market and is taken by a large number of people and companies receive feedback from physicians, patients, nurses, etc. the drug has entered which phase?
Phase 4
What are some factors that led to ethical issues surrounding clinical trials?
1. fewer americans are volunteering
2. companies incur large research and developmental cost
3. FDA imposes rigid regulations
Drugs are given 3 names. The name related to the chemical structure of the girl is the ________ name
Chemical
The name assigned to the drug when the pharmaceutical company applies for the approval process is the __________ name,
Generic
The name selected by the pharmaceutical company for a drug is the ______.
Brand name
Mr. Jones orders his meds online because they are much cheaper, however, he's at risk for receiving ________ drugs.
counterfeit
A reputable on-line pharmacy will show the seal ______.
VIPPS Verified Internet Pharmacy Practice Site
The American Nurses Association Code of Ethics for Nurses states a nurse's responsibility is _____
do no harm to others
don't give harmful medication
administer medication safely and ethicly
These are written to protect the residents of the state by maintaining minimum safe standards for nursing.
Nurse practice acts
true or false
University Hospital policies requires bed ridden patients to be turned every 3 hours. State nurse practice acts requires bed ridden patients to be turned every 2 hours. All agencies have legal policies.
False.
The agency (University Hospital) can not have broader policies then the nurse practice act. Patients must at LEAST be turned every 2 hours.
What is required for a valid order?
patient's name
time/date order is written
name or drug
dosage
route
frequency
signature of person writing order
What is a nurse responsible for knowing about a drug s/he will administer?
purpose, therapeutic effects, and possible adverse effects
alert to drug-drug and food-drug interactions
What code defines moral, ethical and legal concepts and sets guidelines for conducting scientific research on human studies?
The Nuremberg Code
This board is required to approve and monitor human experimentation at institutions conducting research.
Institutional Review Board
bid
twice a day
tid
three times a day
qid
4 times a day
qh
every hour
q 2 h
every 2 hours
prn
as needed
stat
immediately
ac
before meals
pc
after meals
c
with
s
without
IVP
intravenous push
IVPB
intravenous piggy-back
PO
BY MOUTH
NPO
nothing by mouth
SQ
subcutaneous
SL
sublingual
R
rectal
NGT
naso-gastric tube
A drug administered through NG tube is disintegrated and dissolved by fluids in the stomach and small intestine. This drug is in which phase of drug activity?
pharmaceutical phase

(only drugs administered through the GI tract experience this phase)
The movement of a drug from the site of entry into the body's blood strem is called _____
absorption
The movement of a drug from the blood stream into the interstitial space and into the cell is called ______.
distribution
the movement of a drug through absorption and distribution is found in which phase of drug activity?
pharmacokinetic
the bio-chemical actions of drugs and the physiological responses to drugs is found in which phase of drug activity?
pharmacodynamic
when a drug goes through metabolism and excretion it it in which phase of drug activity?
pharmacokinetic
A tablet or capsule that have properties that allow rapid or slow disintegration and dissolution (ex. enteric coating) affect which phase of drug activity?
pharmaceutical phase
the low pH found in the stomach will affect which phase of drug activity?
pharmaceutical phase
A capsule may stick to the tongue of an elderly, debilitated, or confused patient and this will affect which phase of drug activity?
pharmaceutical phase
The percentage of the drug dosage that reaches the systemic circulation is called __________
bioavailability
What factors effect bioavailability?
route of administration
degree of first pass effect
degree of second pass effect
True or Flase
IV drug administration provides the greatest bioavailability?
True because it is delivered directly into the bloodstream
True or False
Oral drugs provides the greatest bioavailability?
False there are many factors that can affect the drug in the GI tract.
A drug that passes from the intestinal lumen to the liver and is partially inactivated before reaching the systemic circulation. This is called ____
first pass effect
This occurs when the liver excretes unmetabolized drug into the bile and the gut reabsorbs it.
second pass effect
A drugs rate of absorption will effect which phase of drug activity?
pharmacokinetic phase
A decrease in the number of mucosal microvilli in the small intestine will effect which phase of drug activity?
pharmacokinetic phase
Gastric motility, how fast or slow a drug moves a drug moves from the stomach to the small intestine effects which phase of drug activity?
pharmacokinetic phase
The presence or absence of food will effect which phase of drug activity?
pharmacokinetic phase
Certain foods and drugs affect a drugs rate of absorption, which in turn effect which phase of drug activity?
pharmacokinetic phase
Poor circulation of blood delays distribution of drug and affects which phase of drug activity?
pharmacokinetic phase
The amount of drug that is bound to protein is _______ while the amount of free drug is _______.
inactive

active
A large amount of circulating free drug could result in _______.
toxicity
Malnutrition can cause low levels of plasma proteins. This reduces the number of plasma protein binding sites which results in _____
increased amounts of free drug and toxicity can occur
A person with liver disease has a decreased ability to metabolize drugs and this will affect which phase of drug activity?
pharmacokinetic phase
The time it takes for one half of a drugs concentration to be eliminated is ____
the half length
The length of a drug's half life can affect which phase of drug activity?
pharmacokinetic phase
Renal disease impairs the kidneys from excreting the metabolized drug. This affects which phase of drug activity?
pharmacokinetic phase
The greater the fit between the drug and the receptor site, the more effective the drug and the fewer side effects or adverse reactions. This affects which phase of drug activity?
pharamcodynamic phase
Some drugs cause an enzyme to to bind with the drug instead of its target cells, therefore inhibiting the action of that specific enzyme, This can affect which phase of drug activity?
pharamcodynamic phase
The use of multiple medications by one patient is called _______
polypharmacy
How can polypharmacy affect drug therapy?
Many different drugs can cause drug-drug interactions and can increase or decrease actions of drug
Drugs have a range of minimum to maximum doses that will exert a therapeutic response, this is called
Dose response or dosage range
A dose that is too small is _______ and a dose that is too large can be _____. Both affect drug therapy.
subtherapeutic

toxic
Evidence that a drug is exerting a therapeutic response is called ______
efficacy
Over time larger doses of a drug is needed to achieve the same effect because of excess drug metabolizing enzymes and/or decreased sensitivity at receptor sites is called _____
Tolerance
What weight is targeted for the recommended dosage of a drug?
150 lbs
How does age affect drug therapy?
Children and elderly patients usually require smaller dosages of drugs.
True or False
Gender is not a factor that affects drug therapy.
False Women and me respond differently to many drugs
Differences in genetic makeup can cause varied responses to drugs and affects drug therapy. This is also termed ________.
pharmacogenetics
Drug therapy is affected by a person's knowledge of a drug and attitude toward taking the drug, which is also termed _____.
psycho-social factors
A drug is more effective when administered at night this is referred as _____.
diurnal response
Drug therapy is affected by the time it takes the drug to reach the minimum effective concentration, which is termed _____.
onset of action
When the drug reaches the highest level of concentration is called ______.
Peak Action
The length of time a drug has a pharmacological effect or how long the drug works is called _____.
Duration of action
The ratio between the effective dose and the lethal dose is called _____.
therapeutic index
The ratio between the minimum effective concentration and the minimum toxic concentration is called _____.
therapeutic range
The peak level indicates the rate of _____.
absorption
The trough levels indicates the rate of ______.
excretion
The half-life of a drug determines the _____.
dosing intervals
A large initial dose that is given to quickly achieve a therapeutic blood level of a drug is called _______.
loading dose
When a drug effects undesired receptors is called _____.
side effects
A physiological response that is harmful to the body and can be potentially life-threatening is called _____.
adverse reaction
An unexpected response from a drug is called _____.
Idiosyncratic response
Drugs may accumulate in drug "reservoirs" such as bone, adipose tissue and the liver resulting in a greater than desired pharmacological effect is called _____.
cumulation
When two or more drugs with similar actions are given simultaneously to increase the pharmacological effect is called _____.
summation
When two or more drugs with dissimilar actions are given simultaneously to create a pharmacological effect that is greater than if the drugs were given independently is called
potentiation
A indication that a particular drug should not be given is called ______.
contraindication
When a patient deviates from the therapeutic regimen due to factors as lack of knowledge, lack of commitment or environmental factors is called _____.
non-adherance/ non-compliance
An unfavorable event resulting from therapeutic interventions is called ______.
iatrogenic effect
Iatrogenic effects such as nausea, vomiting, diarrhea, gastric mucosal irritation and stomatitis are examples of ________.
gastro-intestinal effects
iatrogenic effect of decreased red and/or white blood cells (blood dyscrasias) is called _______.
hematologic effect
Monitor for increase in liver enzymes such as AST, ALP, and ALT in which iatrogenic effect?
hepatotoxicity (liver failure)
Monitor for increase in the blood urea nitrogen (BUN) and the serum creatinine in which iatrogenic effect?
nephrotoxicity (kidney failure)
Iatrogenic effects such as weight gain, hyperglycemia, fluid and electrolyte imbalances is called ______.
metabolic effects
Iatrogenic effects such as rashes, itching, changes in pigmentation is called ______.
dermatologic effects
iatrogenic effect such as increased reaction of the skin to the sun is called _____
photosensitivity
Iatrogenic effects such as sedation, agitation, psychosis is called _______.
behavioral effect
an iatrogenic effect capable if causing cell mutation leading to carcinoma (cancer) is called ______.
carcinogenic effect
iatrogenic effects that cause developmental disorders in the fetus is called _____.
teratogenic effect
In this category there is no evidence of risk to the human fetus
category A
In this category there are little to no risk to the fetus
category B
In this category animal studies show an adverse effect on the fetus but no human studies have been done. Potential benefits to the mother may outweigh the potential risk to the fetus
category C
In this category there is evidence that there is risk to a human fetus. Potential benefits to the mother may outweigh the potential risk to the fetus
category D
In this category animal and/or human studies show fetal abnormalities or adverse reactions. The risk to the fetus outweighs the potential benefits to the mother.
category X
Anaphylactic shock occurs in which of the 4 types of allergic reactions?
Type 1
Auto-immune response occurs in which of the 4 types of allergic reactions?
Type 2
A delayed reaction occurs in which of the 4 types of allergic reactions?
Type 3
The type of allergic reaction causes sensitized T lympocytes
type 4
The sympathetic nervous system is also known as the _______ system and its primary neurotransmitter are _______.
adrenergic

norepinephrine, epinephrine, dopamine
The sympathetic nervous system is responsible for the _______ response.
fight or flight
The sympathetic nervous system affects what main organs?
heart, lungs, and brain
The parasympathetic nervous system is also known as the ______ system and its primary neurotransmitter is ______.
cholinergic

acetylcholine
The parasympathetic nervous system is responsible for the ______ response.
rest and digest
Adrenergic agonist drugs are also known as ______
sympathomimetics
Adrenergic drugs mimic ____________ and act on one or more adrenergic receptor sites.
norepinephrine, epinephrine, and/or dopamine
What are the adrenergic receptor sites?
alpha 1, alpha 2, beta 1, beta 2 and dopaminergic
When _____ receptors are stimulated by adrenergric drugs, (nor)epinephrine and dopamine are released causing increased cardiac contraction and arterioles and venules vasoconstrict causing increased blood pressure and blood return to heart.
alpha 1
What is the body's response to stimulation of alpha 1 receptors?
increased cardiac contraction.
vasoconstriction of arterioles and venules causing increased blood pressure and blood return to heart
When ______ receptors are stimulated, the release of norepinephine and/or epinephrine is inhibited causing blood pressure to decrease.
alpha 2
What is the body's response when alpha 2 receptors are stimulated?
blood pressure is decreased
When _____ receptors are stimulated (nor)epinephrine and dopamine are released causing cardiac contraction and heart rate to increase, the release of renin to increase and intra-ocular pressure to increase.
beta 1
What is the body's response to the stimulation of beta 1 receptors?
cardiac contraction and heart rate increase. increased release of renin from kidneys and increased intraocular pressure
When ______ receptor's are stimulated epinephrine is released causing bronchioles to dilate and GI and uterine relaxation occurs
beta 2
What is the body's response to the stimulation of beta 2 receptors?
Bronchioles dilate and GI and uterine relax
When ______ receptors are stimulated the coronary, renal, and visceral arterial vessels are dilated to supply oxygen to these organs.
dopaminergic
What are examples of Adrengeric Agonist?
direct-acting (catecholamines) and sympathetic amines (non-catecholamines)
What are examples of direct acting (catecholamines) adrenergic agonist?
epinephrine
norepinephine
dopamine
dobutamine
What adrenergic agonist stimulates alpha 1, beta 1 and beta 2 receptors. Is given for cardiac and respiratory problems and can be given IM, IV, SC and inhalation
epinehprine (adrenaline)
Which direct-acting adrenergic agonist stimulates alpha 1 and beta 1 receptor sites causing vasoconstiction to treat hypotension. Its only given in ICU because it can cause lost of extremities
norepinephrine (Levophed)
Which direct-acting adrenergic agonist stimulates dopaminergic, alpha 1, and beta 1 receptors causing peripheral vasoconstriction while vasodilating vessels to major organs. Used for acute hypotension and improve renal perfusion.
dopamine (intropin)
which direct acting adenergic agonist stimulates beta 1 receptors causing increased cardiac output and used for cardiogenic shock. IV use only
dobutamine (Dobutrex)
Which sympathetic amine selectively stimulates beta 2 receptors and opens up lungs
albuterol (proventil)
Which sympathetic amine stimulates beta 2 receptors and is used to slow/stop contractions in pre-term labor
terbutaline (brethine)
which sympathetic amine stimulates alpha 1 receptors causing nasal mucosal vasoconstriction. also increases BP and HR
psuedoephedrine (sudafed)
When administering Sympathomimetics ______ and ______ should be assessed for those that stimulate alpha 1 and beta 1 receptor sites
tachycardia and hypertension
When administering Sympathomimetics, be caution of patients with _______ disease and _____ disease.
coronary artery disease and hypertensive disease
Drugs that block the effects of the sympathetic neurotransmitters are called _____.
Adrenergic Antagonist Drugs (Blockers/Sympatholytics)
Drugs that are _______ reduce the level of dopamine in the brain and are often used as anti-anxiety and anti-psychotic agents.
anti-dopaminergic
This adrenergic antagonist drug vasodilates arterioles, relax smooth muscles in the urethra and decreases the force of the cardiac contraction.
Alpha 1 Adrenergic Blocker
Isoxsuprine (Vasodilan) causes vasodilation; what type of adrenergic blocker is it?
Alpha 1 blocker
Doxazosin mesylate (Cardura) dilates the urethra and it what type of adrenergic blocker?
alpha 1 blocker
Phentolamine mesylate (Regitine) dilates blood vessels and is what type of adrenergic antagonist?
alpha 1 blocker
Vertigo, palpitations, sexual dysfunction and orthrostatic hypotension are all side effects of what adrenergic antagonist?
alpha 1 blocker
These adrenergic antagonist slow the heart rate, decrease BP through vasodilation and decreased release of renin from the kidneys and the force of cardiac contraction is decreased.
Beta Adrenergic Blockers
Propranolol HCL (Inderal) is used for tachycardia, hypertension, coronary artery disease and migraines; what type of adrenergic antagonist is it?
beta blocker
Metoprolol (Lopressor, Toprol XL) is used for hypertension and coronary artery disease; which type of adrenergic antagonist is it?
beta blocker
Timolol Opthalmic Drops (Timoptic) is used for open angle glaucoma and is which type of adrenergic antagonist?
beta blocker
Which adrenergic antagonist lowers HR, force of cardiac contraction and rate of AV contraction?
beta blocker
Bradycardia, GI disturbance, cardiac heart failure, decreased BP and depression are all side effects of what adrenergic antagonist?
Beta blocker
When administering sympatholytics, monitor blood pressure because ______ can result with any of those drugs
hypotension
When administering sympatholytics monitor for reflex _____ with alpha 1 adrenergic blockers
tachycardia
_________ drugs stimulate the parasympathetic nervous system and mimics neurotransmitter _______.
Cholinergic

acetylcholine
What are the types of cholinergic receptors?
Muscarinic and nicotinic
Muscarinic receptors affect _____
smooth muscles
Nicotinic receptors affect _____
skeletal muscles
______ destroys acetylcholine and by inhibiting it, acetylcholine is available to the receptors for a longer period of time.
acetylcholinesterase
Heart rate decreases, BP decreases, bronchoconstriction occurs, bronchial secretions increase, salivation increases all occur when the ______ system is stimulated
cholinergic
What direct acting cholinergic agonist stimulates urination and increases motility, usually used post-op.
bethanechol (Urceholine)
What acetylcholinesterase inhibitor stimulates urination and increases gastric motility?
neostigmine (Prostigmin)
What acetylcholinesterase inhibitor is used to maintain muscle strength in myasthenia gravis?
pyridostigmine bromide (mestinon)
What acetylcholinesterase inhibitor is used to reduce intraocular pressure
demecarium bromide opthalmic drops (humarsol)
What acetylcholinesterase inhibitor slows progression of Alzheimer's Disease
donepezil (Aricept)
Abdominal cramping, diarrhea, extreme muscle weakness and respiratory distress are all possible side effects of ______.
acetylcholinesterase inhibitors
_____ cholinergic drugs act directly on receptors
direct acting
______cholinergic drugs inhibit the action of acetylchoineesterase
indirect acting
_____ drugs inhibit the action of acetylcholine by competing with it for space on the acetylcholine receptors
cholinergic antagonist
HR rate increase, bronchial secretions decrease, salivation decrease, GI motility decreases are all effects of ____
cholinergic antagonist
Which cholinergic antagonist can be used to dry respiratory tract secretions and can treat bradycardia?
atropine sulfate
Which cholinergic antagonist can be used for irrate bowel syndrome?
dicyclomine HCL (Bentyl)
Which cholinergic antagonist can be used for spastic bladder?
tolterodine tartrate (Detrol)
Dry mouth, dehydration, constipation, urinary retention, increased intraocular pressure and blurry vision can all be side effects of ________
parasympatholytics (cholinergic antagonist)