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26 Cards in this Set
- Front
- Back
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What are the risk factor for non-alcoholic fatty liver disease? |
Truncal obesity Male T2DM Hypertriglceridemia Hypertension |
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Approximately how many people with hepatitis C will go on to get cirrhosis? |
30% |
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What are the four stage of alcoholic liver disease? |
Normal Steatosis- fat within the liver (benign) Steatohepatitis- Fat +inflammation Fibrosis/cirrhosis |
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How might someone with liver disease present? |
Incidental finding non specific symptoms: anorexia, weight loss, lethargy Specific symptoms: Jaundice, pruritus, bleeding varices, ascites/oedema, encephalopathy |
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Which liver disease are associated with joint pain? |
Haemochromatosis Hepatitis B Autoimmune hepatitis
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Which liver diseases display abnormal pigmentation? |
Primary biliary cirrhosis Haemochromatosis |
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Which liver disorder is associated with UC patients? |
Primary sclerosising cholangitis |
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Which disease affects the lungs and the liver? |
Alpha-1- antitrypsin |
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If you have a raised ALP and gamma GT what might that indicate? |
Cholestasis, malignancy or alcohol abuse (gammaGT with MCV) |
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What would and increase in ALT +AST indicate? |
Indicate liver cell damage |
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What level of bilirubin is abnormal? |
>17umol/L |
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Which conditions is high bilirubin unconjugated? |
Gilberts and haemolysis |
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Which clotting studies and proteins are tested? |
Prothrombin time (increased is abnormal) Albumin (reduced is abnormal) |
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Which autoantibodies are tested for and what do they indicate? |
ANA and antiSMA indicate autoimmune hepatitis Anti mitochondrial antibody in primary biliary cirrhosis |
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Which immunoglobulin would be raised in autoimmune hepatitis? |
IgG |
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Which immunoglobulin would be raised in PBC? |
IgM |
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Which immunoglobulin would be raised in alcoholic liver disease? |
IgA |
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What tests are done for hepatitis C? |
HCV antibodies and RNA PCR |
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Why are iron and copper studies done when investigating liver disease? |
Raised ferritin and transferrin saturation would indicate haemochormatosis Low caerulopasmin in Wilson's disease |
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Which tumour marker indicated HCC? |
alpha fetoprotein |
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Which tumour marker is raised in cholagnocarinoma? |
CA19-9 |
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Which imaging is first line in liver disease? |
Ultrasound |
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What can a CT be good for when assessing the liver? |
Shows focal liver lesions >5mm Can assess liver architecture May show varices and evidence of portal hypertension Can assess vasculature (e.g pre transplant) |
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What is an example of a good non-invasive investgation of the biliary tree? |
MRCP |
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What is ERCP used to treat? |
Gallstones |
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What are the indications for a liver biopsy? |
Chronic liver disease: diagnosis, staging Focal lesions (guided) Post transplant: rejection |
