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9 Cards in this Set
- Front
- Back
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What are examples of hydrolytic enzymes targeted to the lysosome by M-6-P?
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Proteases, Nucleases, Glycosidases, Lipases, Phospholipases
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what factors help protect the lysosomal membrane against hydrolytic enzymes?
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Glycosylated proteins on the lumenal side,
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By how many pathways do lysosome membrane proteins reach the lysosome? What are they?
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2. The consitutive secretory pathway and the golgi derived secretory pathway.
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What are the pathways by which materials destined for degradation reach the lysosome?
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Phagosome: Material is phagocytosed and the phagosome fuses with lysosome form phagolysosome.
Endosomes: endocytic pathway, finally at end delivered to lysosome for degradation Autophagy: cytoplasmic proteins and entire organelles are targeted by lysosome for destruction. |
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what kinds of autophagy are there?
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macroautophagy, microautophagy, chaperone-mediated autophagy.
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what is tay-sachs disease?
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a lysosomal galactosidase that is absent in neurons - wtf? this barely makes sense
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Proteosome
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Barrel-shaped protein complex made of 7 proteins including proteases and an ATPase
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Peroxisomes
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Catalase, Peroxidases
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what is zellweger syndrome?
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It is caused by a mutation in a gene for peroxisomal targeting receptor.
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