Cs2 - Vasculitis

Front 1

What is the most classic presentation of leukocytoclastic vasculitis?

Back 1

Palpable purpura.

Front 2

What are 3 scenarios that yu see leukocytoclastic vasculitis?

Back 2

Serum Sickness (drug rxn)

Henoch Schonlein Purpurs

Essential mixed cryoglobulinemia

Front 3

Palpable purpura with no other associated signs or symptoms is indicative of _

Back 3

a drug rxn (serum sickness)

(this is small vessel vasculitis aka leukocytoclastic vasculitis)

Front 4

Henoch-Schonlein Purpura typically occurs in who during _ time of the year

Back 4

children during spring time (indicating involvement of an environmental microorganism)

Front 5

What is the presumptive mechanism f Henoch-Schonlein Purpura

Back 5

(this is a small vessel vasculitis, aka leukocytoclastic vasculitis) - it is IgA immune complex mediated

Front 6

What are typical findings in Henoch-Schonlein purpura?

Back 6

Purpura, GI bleeding,

arthritis, nephropathy

Front 7

Essential Mixed Cryoglobulinemia is a _ vessel vasculitis, and is _ mediated.

This is highly associated with what underlying disorder?

Back 7

small vessel vasculitis (leukocytoclastic vasculitis)

Cold temperature mediated -IgG /IgM complex mediation

Hepatitis C

Front 8

Pt presents with lower extremity "bruises that won't go away" and joint pain. Upon physical exam, you note that the brown papules on her legs are slightly palpable. When you place an ice cube on her arm, she breaks out in a rash. What is the dx?

Back 8

Essential Mixed Cryoglobulinemia, this is a leukocytoclastic vasculitis

Front 9

Pt presents with lower extremity "bruises that won't go away" and joint pain. Upon physical exam, you note that the brown papules on her legs are slightly palpable. When you place an ice cube on her arm, she breaks out in a rash. What underlying disorder is this associated with?

Back 9

(the patient has Essential Mixed Cryoglobulinemia)

Ass with HEPATITIS C

Front 10

Take home points of Essential Mixed Cryoglobulinemia?

Back 10

Small Vessel vasculitis,

Cold temp precipitation of IgG/IgM complexes

Associated with Hep C

Front 11

Take home points of Henoch-Schonlein Purpura?

Back 11

Small Vessel vasculitis

typically in children, IgA complex deposition resulting in purpura, GI bleeding (arthritis and nephropathy less common)

Front 12

What vasculitis disorder is characterized by Segmental necrotizing inflammation of arteries involving bifurcations and branch points (It does not involve veins

Back 12

Polyarteritis Nodosa

It is associated with Hepatitis B

Front 13

Pt is diagnosed with Polyarteritis Nodosa. Where would you expect to NOT find any lesions?

Back 13

Lung

(compare to Churg - Strauss, another medium vasculitis that does involve the lung)

Front 14

The diagnosis of polyarteritis nodosa is based on _ and _

Back 14

clinical suspicion and radiographical images

Front 15

Churg-Strauss is AKA _

There is a strong association is _

Back 15

allergic granulomatosus

(this is where the tissues are filled with eosinophils)

asthma/allergy history

Front 16

A granulomatous reaction where the tissues are filled with eosinophils

Back 16

Churg - Strauss ( a medium vasculitis)

Front 17

Eosinophilia, neuropathy, transitory pulmonary infiltrates, paranasal sinus abnormalities and asthma are all criteria for the diagnosis of what vasculitis?

Back 17

Churg Strauss (allergic granulomatosus)

Front 18

Wegener's Granulomatosis affects what size vessel?

It is highly associated with _

Back 18

small and medium arteries

C ANCA antibody (specifically PR3)

Front 19

The ELK classification is diagnostic for what vasculitis?

Back 19

Wegener's Granulomatosis

stands for ENT, Lungs, Kidney

Typically these patients have a history of chronic nasal infections

Front 20

Takayasu's Arteritis is classically seen in _.

This has a strong preference to what vessels?

Back 20

young asian women

aortic arch and it's branches

Front 21

An abormal arteriogram - showing occlusion or narrowing of proximal aorta or it's main branches is diagnostic of what vasculitis?

Back 21

Takayasu's Arteritis

Front 22

Temporal arteritis is classically seen in _.

Back 22

older women

(with jaw claudication, visual changes, or new headache)

Front 23

A 70 yo women presents with a new onset headache, visual changes and jaw claudication. ESR level is 85. What is the vasculitis disorder that you should consider in this patient?

Back 23

Temporal Arteritis

Front 24

With regards to vasculitis, it is important to look at your patients from what standpoint?

Back 24

An organ system....

this helps you diagnose the problem

Front 25

Most vasculitites are assumed to be mediated by _ mechanisms that occur in response to _.

Back 25

immunopathogenetic mech

response to certain antigenic stimuli

Front 26

What are the 3 proposed mechanism of vascular damage that cause vasculitis?

Back 26

1. Pathogenic immune complex form/deposition 2. Production of ANCA or 3. Pathogenic T lymph responses and granuloma form.

Front 27

The distribution and therefore clinical symptoms of vasculitis depend on _

Back 27

the vessel size

Front 28

What are the main symptoms of large vessel vasculitis?

Back 28

limb claudication, asymmetric BP, absence of pulses, bruits, aortic dilation

Front 29

limb claudication is a symptom of what group of vasculitities?

Back 29

Large Vessel

Front 30

What are the symptoms for medium vessel vasculitis?

Back 30

cutaneous nodules, ulcers, digital gangrene

Front 31

What are the symptoms of small vessel vasculitis?

Back 31

purpura, vesiculobullous lesions, urticarial, glomerulonephritis

Front 32

How are vasculitities typically treated?

Back 32

glucocorticoids (anti- inflammatories) and immunosuppressives.

Start strong and step down once the pt starts responding

Front 33

_ vasculitis is associated with hepatitis C

Back 33

essential mixed cryoglobulinemia

Front 34

_ (vasculitis) is associated with hepatitis B

Back 34

Polyarteritis Nodosa