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28 Cards in this Set
- Front
- Back
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What are the 4 disorders/syndromes discussed in the CT lecture?
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1. Systemic Lupus Erythematous 2. Scleroderma 3. Sjogren’s Syndrome 4. Polymyositis/Dermatomyositis
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Regarding the diagnostic criteria for Lupus, a patient who has _/11 most likely has lupus
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4
DOPAMINE RASH |
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A discoid rash is characterized by _
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"SEAT" Scaly. Erythematous, Central Atrophy, Telangiectasia
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dsDNA antibodies are highly associated with what type of patients?
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Lupus Patients with renal involvement
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Drug induced SLE is most commonly seen in patients who are _
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slow acetylators
(SHIPP drugs - Sulfas, Hydralazine, INH, Procainamide, Phenytoin) |
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Drug induced Lupus is associated with what lab results?
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Anti histone bodies
+ANA |
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There is no _ or _ involvement in Drug Induced Lupus
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renal or CNS
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neonatal lupus is associated with what lab findings?
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Anti Ro (SSA) or La (SSB)
Neonates get these from the mom, they do not manufacture them by themselves. Therefore, the condition typically improves over time unless they developed a heart block |
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Neonates don't manufacture SSA or SSB antibodies on their own (they are acquired from their mother). Therefore, neonatal lupus typically improves over time, with one exception. What is it?
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Permanent Heart Block
If the fetus is exposed to the antibodies between 16-24 weeks, they are at risk for developing any stage heart block |
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Looking at _ can help you determine whether Raynauds is primary or secondary
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Nailfolds under microscopy
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Scleroderma is a syndrome characterized by __ (4)
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Raynauds (persistent vasospasms),
Cutaneous involvement (fibrotic changes of skin), Sclerodactyly (ischemia causes pointing of fingers), and Renal Involvement (arcuate artery ischemia). |
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Scleroderma can be _ or _. What form is more severe?
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Diffuse or Limited.
Diffuse is more severe |
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What are the hallmarks of scleroderma?
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microangiopathy and fibrosis of the skin
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Limited scleroderma patients have a higher risk for _ and _
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pulmonary fibrosis and digital ischemia (finger loss)
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Diffuse scleroderma involves _ and _
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thickening of truncal skin and fibrosis of internal organs
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Limited Scleroderma is AKA
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CREST syndrome. stands for
for antiCentromere, Calcinosis, Reynauds, Esophageal dysmotility, Sclerodactly, Telangectasia |
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What antibody is associated with Limited Scleroderma?
What antibody is associated with diffuse scleroderma? |
antiCentromere
Anti SCL 70 |
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Inflammatory muscle disease involves 2 disorders. What are they, and what's the difference?
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Dermatomyositis, and polymyositis.
Derm involves the skin |
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10% of patients with dermatomyositis have _
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an underlying neoplasia
(it is a paraneoplastic syndrome) |
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What CT disorder is also considered a paraneoplastic syndrome?
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dermatomyositis
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Gottron's patches, heliotrope, V neck erythema are characteristics of what disorder?
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Dermatomyositis
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Inflammatory muscle disease, such as dermatomyositis and polymyositis typically involve what muslces?
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proximal muscles (shoulder and hip girdles)
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How do you treat Scleroderma?
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Ca channel agents (vasodilators) for raynauds.
Every patient is also on a proton inhibitor Other than than, treat symptomatically |
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What antibodies are produced by patients with Sjogrens?
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Rheumatoid Factor
SSA SSB |
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Sjorgren's patients are RF (+/-)
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+
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How do you treat inflammatory muscle disease?
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corticosteroids, methotrexate
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What is the process skin goes through in scleroderma?
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An inflammatory rxn, color changes, induration and atrophy, telangiectasia and calcinosis
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_ Is a disease that results from increased collagen deposition causing vascular obliteration and fibrosis of visceral organs and skin
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Sclerodema
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