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94 Cards in this Set

  • Front
  • Back
Trazadone SE
Priapism
Aspirin SE
GI bleed, hypersensitivity
Bleomycin SE
Pulm fibrosis
Cyclopyosphate SE
Hemorrhagic cystitis
Buproprion SE
Seizures
Isoniazid SE
Vitamin B6 deficiency, lupus, liver tox
Cyclosporine class and SE
anti-inflammatory/immune suppressant
Renal tox
Penicillins SE
Anaphylaxis, rash with EBV
ACE inhibitors SE
cough, can damage fetal kidneys
Demeclocycline SE
Diabetes insipidus
Lithium SE
Diabetes insipidus, thyroid dyfx
Methoxyflurane class and SE
general anesthetic
Diabetes insipidus
Diabetes Insipidus (3)
Demeclocycline, Lithium, Methoxyflurane
Sulfa drugs SE
Allergies, kernicterus in neonates
Halothane SE
Liver necrosis
Local anesthetic SE
Seizures
Phenytoin SE
folate deficiency, teratogen, hirsutism
Vincristine SE
Vinblastine SE
1) neurotoxicity (areflexia, peripheral neuritis), paralytic ileus
2)blasts bone marrow (suppression)
Amiodarone SE (8)
Pulmonary fibrosis, corneal deposits, hepatotoxicity, skin deposits leading to photodermatitis, neurologic effects, constipation, CV (bradycardia, heart block, CHF), Thyroid dysfx
Valproic Acid SE
Neural tube defects in offspring
Isotretinoin SE
terrible teratogen
Thioridazine SE
Retinal deposits, cardiac toxicity
Heparin SE
Thrombocytopenia, thrombosis
Vancomycin SE
Red Man syndrome
Clofibrate class and SE
fibric acid derivative

increased GI neoplasms
Tertracyclines SE
photosensitivity, teeth staining in children
Quinolones SE
Teratogens (cartilage damage)
Quinine SE
Cinchonism (tinnitus, vertigo)
Morphine SE
Sphincter of Oddi Spasm
Clindamycin (or any broad spectrum Abx) SE
Pseudomemnbranous Colitis
Chloramphenicol class and SE
broad spectrum bacteriostatic

Aplastic Anemia, gray baby syndrome
Doxorubicin class and SE
onc abx
Cardiomyopathy
Busulfan class and SE
alkylating chemo

Pulmonary fibrosis, adrenal failure
MAO inhibitors SE
Tyramine crisis (wine cheese)
Hydralazine class and SE
vasodilator
Lupus erythematosus
Procainamide class and SE
anti-arrhythmic
Lupus erythematosus
Lupus erythematosus (2)
Hydralazine, procainamide
Minoxidil class and SE
arterial vasodilator
Hirsutism
Aminoglycosides SE
Hearing loss, renal toxicity
Acetaminophen
Liver toxicity (in high doses)
Chlorpropamide use and SE
sufonylurea
SIADH
Oxytocin use and SE
(pitocin) - uterine contxn
SIADH
Opiates
SIADH
Drugs that cause SIADH (3)
Chlorpropamide, Oxytocin, Opiates
Dideoxyinosine (DDI) class and SE
nucleoside reverse transcriptatse inhibitor

Pancreatitis, peripheral neuropathy
Halogen anesthetic SE
Malignant Hyperthermia
Succinylcholine SE
Malignant Hyperthermia
Malignant Hyperthermia
Halogen, Succinylcholine
Zidovudine (AZT) SE
Bone Marrow Suppression
Digitalis class and SE
cardiac glycoside
GI disorders, vision changes, arrhythmias
Acetazolamide class and SE
carbonic anhydrase inhibitor (diamox)
Metabolic acidosis
Trimethadioine use and SE
anti-convulsant for absence seizures

Terrible teratogen
Clozapine SE
Agranulocytosis
SSRIs SE
Anxiety, agitation, insomnia
Warfarin SE
Necrosis, teratogen
Niacin SE
skin flushing, pruritis
HMG CoA reductase SE
Liver and muscle toxicity
Ethambutol use and SE
TB drug
Optic neuritis
Metronidazole SE
DIsulfiram like reaction with etoh
Cisplatin class and SE
alkylating agent
Nephrotoxicity
Methyldopa class and SE
alpha adrenergic antagonist

hemolytic anemia (coomb's positive)
Thiazides SE
hyperglycemia, hyperuricemia, hyperlipidemia, hyponatremia, hypokalemic metabolic alkalosis, hypovolemia, calcium retention, SULFA RXN IN SULFA SENSITIVE Pts
Loop Diuretics SE
hypokalemic metabolic alkalosis, hypovolemia, ototoxicity, calcium excretion, SULFA RXN (except ethacrynic acid)
Carbonic Anhydrase inhibitors SE
metabolic acidosis
Antihypertensives SE
sedation, depression (methyldopa esp.), sexual dysfx
Beta Blockers SE
bradycardia, heart block, CHF in susceptibles, Asthma, masking of hypoglycemia Sx
Calcium Channel Blockers SE
bradycardia, heart block, CHF in susceptibles
Alpha-one antagonists SE
severe first dose orthostatic hypotension
Psych Drugs that cause extrapyramidal SEs
Haloperidol>>Chlorpromazine, Risperidone or Olanzapine
Antipsychotic medications:
High Potency, Low Potency and Atypical
Haloperidol, Chlorpromazine, Risperidone or Olanzapine
Psych Drugs that cause autonomic SEs
Chlorpromazine>>
Risperidone or Olanzapine>
Haloperidol
Extrapyramidal SEs
Acute dystonia (hours/days), Akathisia(days), Parkinsonism (months), Tardive dyskinesia (yrs), Neuroleptic Malignant Syndrome (any time).
Acute dystonia: Sx and Tx
SX: muscle spasms/stiffness (torticollis, trismus), tongue protusions and twisting, opisthotonos, oculogyric crisis (forced sustained deviation of head and eyes
Tx: antihistamines (diphenhydramine) or anticholinergics (benztropine, trihexyphenidyl)
Akathisia: Sx and Tx
subjective restlessness
can try to tx with beta blockers
Parkinsonism: Sx and Tx
stiffness, cogwheel rigidity, shuffling gait, mask like facies and drooling
Tx: antihistamines (diphenhydramine) or anticholinergics (benztropine, trihexyphenidyl)
Tardive Dyskinesia: sx and tx
sx: perioral movements (darting, protruding tongue, chewing, grimacing, puckering), choreoathetoid movements of the head, limbs and trunk
Tx: none - switch antipsychotic (olanzapine, clozapine)
Neuroleptic Malignant Syndrome:Sx and Tx
rigidity, mutism, obtundation, agitation, high fever (up to 107), HIGH CK (>5000), sweating, myoglobinuria
Tx: First d/c antipsychotic,
Second, supportive tx
Third, dantrolene (like in malignant hyperhthermia
Autonomic Side Effects
anticholinergic (dry mouth, urinary retention, blurry vision, mydriasis), alpha 1 blockade (orthostatic hypotension), and antihistamine effects (sedation)
Antidote to Acetaminophen Poisoning
Acetylcysteine
Antidote to Cholinesterase Inhibitors poisoning
Atropine, pralidoxime
Antidote to Quinidine or tricyclic antidepressants poisoning
Sodium bicarbonate (cardioprotective)
Antidote to Iron poisoning
Deferoxamine
Antidote to Digoxin poisoning
normalize K+ and other lytes, digoxin Ab
Antidote to Methanol or ethylene glycol poisoning
ethanol
Antidote to Benzodiazepines poisoning
Flumazenil
Antidote to Beta blockers poisoning
glucagon
Antidote to Lead poisoning
Edetate
Antidote to Copper/gold poisoning
Penicillamine
Antidote to Opioids poisoning
Naloxone
Antidote to Carbon Monoxide Poisoning
Oxygen (hyperbaric if severe)
Antidote to Muscarinic receptor blockers poisoning
Physostigmine
Drug interactions with MAO inhibitors (2)
Meperidine (coma)
SSRIs (SSRI syndrome: hyperthermia, rigidity, myoclonus, autonomic instability)
Drug interaction with Aminoglycosides
loop diuretics (enhanced ototoxicity)
Drug interaction with Thiazides
lithium (lithium tox)