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94 Cards in this Set
- Front
- Back
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Trazadone SE
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Priapism
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Aspirin SE
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GI bleed, hypersensitivity
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Bleomycin SE
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Pulm fibrosis
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Cyclopyosphate SE
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Hemorrhagic cystitis
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Buproprion SE
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Seizures
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Isoniazid SE
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Vitamin B6 deficiency, lupus, liver tox
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Cyclosporine class and SE
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anti-inflammatory/immune suppressant
Renal tox |
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Penicillins SE
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Anaphylaxis, rash with EBV
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ACE inhibitors SE
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cough, can damage fetal kidneys
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Demeclocycline SE
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Diabetes insipidus
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Lithium SE
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Diabetes insipidus, thyroid dyfx
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Methoxyflurane class and SE
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general anesthetic
Diabetes insipidus |
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Diabetes Insipidus (3)
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Demeclocycline, Lithium, Methoxyflurane
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Sulfa drugs SE
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Allergies, kernicterus in neonates
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Halothane SE
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Liver necrosis
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Local anesthetic SE
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Seizures
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Phenytoin SE
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folate deficiency, teratogen, hirsutism
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Vincristine SE
Vinblastine SE |
1) neurotoxicity (areflexia, peripheral neuritis), paralytic ileus
2)blasts bone marrow (suppression) |
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Amiodarone SE (8)
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Pulmonary fibrosis, corneal deposits, hepatotoxicity, skin deposits leading to photodermatitis, neurologic effects, constipation, CV (bradycardia, heart block, CHF), Thyroid dysfx
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Valproic Acid SE
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Neural tube defects in offspring
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Isotretinoin SE
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terrible teratogen
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Thioridazine SE
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Retinal deposits, cardiac toxicity
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Heparin SE
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Thrombocytopenia, thrombosis
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Vancomycin SE
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Red Man syndrome
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Clofibrate class and SE
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fibric acid derivative
increased GI neoplasms |
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Tertracyclines SE
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photosensitivity, teeth staining in children
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Quinolones SE
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Teratogens (cartilage damage)
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Quinine SE
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Cinchonism (tinnitus, vertigo)
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Morphine SE
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Sphincter of Oddi Spasm
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Clindamycin (or any broad spectrum Abx) SE
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Pseudomemnbranous Colitis
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Chloramphenicol class and SE
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broad spectrum bacteriostatic
Aplastic Anemia, gray baby syndrome |
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Doxorubicin class and SE
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onc abx
Cardiomyopathy |
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Busulfan class and SE
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alkylating chemo
Pulmonary fibrosis, adrenal failure |
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MAO inhibitors SE
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Tyramine crisis (wine cheese)
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Hydralazine class and SE
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vasodilator
Lupus erythematosus |
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Procainamide class and SE
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anti-arrhythmic
Lupus erythematosus |
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Lupus erythematosus (2)
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Hydralazine, procainamide
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Minoxidil class and SE
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arterial vasodilator
Hirsutism |
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Aminoglycosides SE
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Hearing loss, renal toxicity
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Acetaminophen
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Liver toxicity (in high doses)
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Chlorpropamide use and SE
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sufonylurea
SIADH |
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Oxytocin use and SE
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(pitocin) - uterine contxn
SIADH |
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Opiates
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SIADH
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Drugs that cause SIADH (3)
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Chlorpropamide, Oxytocin, Opiates
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Dideoxyinosine (DDI) class and SE
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nucleoside reverse transcriptatse inhibitor
Pancreatitis, peripheral neuropathy |
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Halogen anesthetic SE
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Malignant Hyperthermia
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Succinylcholine SE
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Malignant Hyperthermia
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Malignant Hyperthermia
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Halogen, Succinylcholine
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Zidovudine (AZT) SE
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Bone Marrow Suppression
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Digitalis class and SE
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cardiac glycoside
GI disorders, vision changes, arrhythmias |
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Acetazolamide class and SE
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carbonic anhydrase inhibitor (diamox)
Metabolic acidosis |
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Trimethadioine use and SE
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anti-convulsant for absence seizures
Terrible teratogen |
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Clozapine SE
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Agranulocytosis
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SSRIs SE
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Anxiety, agitation, insomnia
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Warfarin SE
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Necrosis, teratogen
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Niacin SE
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skin flushing, pruritis
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HMG CoA reductase SE
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Liver and muscle toxicity
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Ethambutol use and SE
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TB drug
Optic neuritis |
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Metronidazole SE
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DIsulfiram like reaction with etoh
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Cisplatin class and SE
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alkylating agent
Nephrotoxicity |
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Methyldopa class and SE
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alpha adrenergic antagonist
hemolytic anemia (coomb's positive) |
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Thiazides SE
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hyperglycemia, hyperuricemia, hyperlipidemia, hyponatremia, hypokalemic metabolic alkalosis, hypovolemia, calcium retention, SULFA RXN IN SULFA SENSITIVE Pts
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Loop Diuretics SE
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hypokalemic metabolic alkalosis, hypovolemia, ototoxicity, calcium excretion, SULFA RXN (except ethacrynic acid)
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Carbonic Anhydrase inhibitors SE
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metabolic acidosis
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Antihypertensives SE
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sedation, depression (methyldopa esp.), sexual dysfx
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Beta Blockers SE
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bradycardia, heart block, CHF in susceptibles, Asthma, masking of hypoglycemia Sx
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Calcium Channel Blockers SE
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bradycardia, heart block, CHF in susceptibles
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Alpha-one antagonists SE
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severe first dose orthostatic hypotension
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Psych Drugs that cause extrapyramidal SEs
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Haloperidol>>Chlorpromazine, Risperidone or Olanzapine
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Antipsychotic medications:
High Potency, Low Potency and Atypical |
Haloperidol, Chlorpromazine, Risperidone or Olanzapine
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Psych Drugs that cause autonomic SEs
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Chlorpromazine>>
Risperidone or Olanzapine> Haloperidol |
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Extrapyramidal SEs
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Acute dystonia (hours/days), Akathisia(days), Parkinsonism (months), Tardive dyskinesia (yrs), Neuroleptic Malignant Syndrome (any time).
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Acute dystonia: Sx and Tx
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SX: muscle spasms/stiffness (torticollis, trismus), tongue protusions and twisting, opisthotonos, oculogyric crisis (forced sustained deviation of head and eyes
Tx: antihistamines (diphenhydramine) or anticholinergics (benztropine, trihexyphenidyl) |
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Akathisia: Sx and Tx
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subjective restlessness
can try to tx with beta blockers |
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Parkinsonism: Sx and Tx
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stiffness, cogwheel rigidity, shuffling gait, mask like facies and drooling
Tx: antihistamines (diphenhydramine) or anticholinergics (benztropine, trihexyphenidyl) |
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Tardive Dyskinesia: sx and tx
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sx: perioral movements (darting, protruding tongue, chewing, grimacing, puckering), choreoathetoid movements of the head, limbs and trunk
Tx: none - switch antipsychotic (olanzapine, clozapine) |
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Neuroleptic Malignant Syndrome:Sx and Tx
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rigidity, mutism, obtundation, agitation, high fever (up to 107), HIGH CK (>5000), sweating, myoglobinuria
Tx: First d/c antipsychotic, Second, supportive tx Third, dantrolene (like in malignant hyperhthermia |
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Autonomic Side Effects
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anticholinergic (dry mouth, urinary retention, blurry vision, mydriasis), alpha 1 blockade (orthostatic hypotension), and antihistamine effects (sedation)
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Antidote to Acetaminophen Poisoning
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Acetylcysteine
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Antidote to Cholinesterase Inhibitors poisoning
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Atropine, pralidoxime
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Antidote to Quinidine or tricyclic antidepressants poisoning
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Sodium bicarbonate (cardioprotective)
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Antidote to Iron poisoning
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Deferoxamine
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Antidote to Digoxin poisoning
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normalize K+ and other lytes, digoxin Ab
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Antidote to Methanol or ethylene glycol poisoning
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ethanol
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Antidote to Benzodiazepines poisoning
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Flumazenil
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Antidote to Beta blockers poisoning
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glucagon
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Antidote to Lead poisoning
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Edetate
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Antidote to Copper/gold poisoning
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Penicillamine
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Antidote to Opioids poisoning
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Naloxone
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Antidote to Carbon Monoxide Poisoning
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Oxygen (hyperbaric if severe)
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Antidote to Muscarinic receptor blockers poisoning
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Physostigmine
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Drug interactions with MAO inhibitors (2)
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Meperidine (coma)
SSRIs (SSRI syndrome: hyperthermia, rigidity, myoclonus, autonomic instability) |
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Drug interaction with Aminoglycosides
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loop diuretics (enhanced ototoxicity)
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Drug interaction with Thiazides
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lithium (lithium tox)
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