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18 Cards in this Set
- Front
- Back
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Morphogenesis
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describes the sequence of events that forms the structure of an organism
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Three aspects to Morphogenesis
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Cellular level (mitosis and differentiation)
Cell migration (embryo development) Apoptosis (programmed cell death) |
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Homotypic
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these interactions are b/t cells that have similar origin / fate
Ex: dental lamina induces all IEE cells to become ameloblasts and make enamel |
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What type of cell interaction is occurring when gap junctions allow chemical signals to pass b/t epithelial cells causing dental lamina to induce IEE to become ameloblasts?
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Homotypic Cell Interaction
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Heterotypic
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these interactions are b/t cells that have different origin / fate
Ex: IEE induces dental papilla to become odontoblasts and make dentin Then dentin induces IEE to become ameloblasts and make enamel Two different origins |
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What type of cell interaction is occurring when IEE induces dental papilla to become odontoblasts to make dentin which in turn induces IEE to become ameloblasts and make enamel?
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Heterotypic Cell Interaction
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Function of Transcription Factors
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nuclear proteins that regulate gene expression by binding to DNA
regulate the architectural plan in the formation of the craniofacial area regulates the fate of the cell |
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Homeobox Genes
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regulatory genes that exist as little clusters on certain chromosomes
common a homeobox domain = same 180 base pair sequence |
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Homeobox Domain
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180 base pair sequence common to all homeobox genes
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Hox Cluster Genes
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determine the architecture of the whole organism
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Growth Factors
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diffusible chemical signals that activate receptors to exert certain effects
Ex: Transforming Growth Factor Beta Bone Morphogenic Proteins Epidermal Growth Factor Fibroblast growth Factors |
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Fibroblast growth Factors
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Growth Factors
plays a role in repairing underlying connective tissue Plays a role in wound healing of soft tissues |
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Epidermal Growth Factor
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Growth Factors
plays a role in repairing stratified squamous epithelium Plays a role in wound healing of soft tissues |
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Bone Morphogenic Proteins
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Growth Factors
Released by IEE stimulates dental papilla mesenchyme to differentiate into odontoblasts and produce dentin also induces repair / growth of cartilage and bone |
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Transforming Growth Factor Beta
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Growth Factors
affects the growth of the body |
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tooth agenesis
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MSX-1 gene had a proline substitution instead of arginine
autosomal dominant gene resulted in the same exact teeth missing in every single member of the family most commonly missing = 3rd molars, 2nd PM |
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MSX-1 gene
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Homeobox gene
Has arginine group play an important role in forming the dentition and palate |
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Craniosynostosis
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involves MSX-1 and MSX-2 genes
calvarial bone (skull cap) development is controlled by signals from dura mater dura mater sends signals to make sure the CT fontanelles open to allow growth & expansion early fusion of bone-bone sutures inhibits brain growth & development |
