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22 Cards in this Set
- Front
- Back
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What drugs inc Li levels?
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thiazides, loops, ACEI, ATII antag, NSAIDs, clonazepam
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What drugs dec Li levels?
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acetazolamide, xanthine, Na-bicarb
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What does Li do to kidney?
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inhibits aquaporin 2 thereby opposing ADH and aldos causing vol depletin and reabs of Li
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Wher in the kidney does lead cause problems?
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PCT - Fanconi's syn
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What is mechanism of toxicity of Hg?
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sulfhydral binding and enz inhibition - nonspecific cell injury/death
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What are the 3 forms of Hg and their absorption?
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elemental (inhalation), inorganic and organic (GI abs)
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What are the 5 effects of Hg poisioning?
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erethism, mercurialaentis, cancer, repro hazard, contact dermatitis
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What is the vaccine preservative that contains Hg?
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thimerosal
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What is used to assess thimerosal exposure to Hg but underestimates the safe exposure?
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MeHg
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What traps Cd in kidneys?
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metallothionen which contains cysteine
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What are effects of Cd toxicity?
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PCT dysfunction leading to proteinuria, gout, and dec GFR
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What is itai-itai dz?
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Japanese dz related to Cd exposure causing osteomalacia and osteoporosis, and irreversible proximal tubule dys
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What is MOA of chelation?
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formation of metal ion complexed w/ electron donor which makes the metal water soluble to be excreted from kidney
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What agent in used to chelate iron?
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deferoxamine
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What metals is dimercaprol used for?
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As, Hg, Au, Pb
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What metals can dimercaperol not be used for?
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Fe, Cd, Methyl Hg, Se
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What is a major SE of dimercaprol?
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nephrotoxicity
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What metals does CaNa2EDTA chelate?
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any metal with higher binding affinity than Ca++
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What is major SE of CaNa2EDTA?
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severe proximal tubule degeration
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What are advantages of succimer (DMSA) over dimercaperol?
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more water sol, high TI, can be given orally, ective in EC space
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How is dimercaperol admin?
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parenterally
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What are indicationsof D-Penicillamine?
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lead poisoning in kids, Cu poisoning in Wilson's dz
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