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7 Cards in this Set
- Front
- Back
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What gives NSAIDs their anti-inflammatory effects?
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The theraputic effects are due to the inhibition of PG-E2 (increases vascular permeability and vasodilation) and PG-I2 (increases vasodilation and platlet aggregation) |
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What give NSAIDs their analgesic effects? |
By decreasing the the synthesis of PG-E2 which causes or enhances pain caused by other agents |
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What gives NSAIDs their antipyretic effects? |
By decreasing the PG-E2 in the hypothalamus, as PG-E2 induces fever and increases the production of IL-6 which further mediates fever |
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What are the general side effects of NSAIDs? |
- Gastric irritation - Increased ble |
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What side effects in the GI are caused by NSAIDs? |
Associated with the inhibition of COX-1 which inhibits the excretion of GI mucosa and increases gastric acid excretion. This can lead to: - Gastric bleeding and ulceration - N, V & D - indigestion |
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What side effects in the kidneys are caused by NSAIDs? |
Some patients can suffer from acute renal insufficiency, this is due to the inhibition of PG-E2 and PG-I2 that are responsible for proper renal flow |
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What are the possible CV side effects associated with NSAIDs? |
associated with an increased risk of thrombotic events such as MI and stroke. This can be attributed to the decreased production of PG-I2 which is associated with vasodilation and inhibition of platelet aggregation |
