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32 Cards in this Set
- Front
- Back
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What is the natural reservoir of Corynepbacterium diphtheriae?
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Respiratory tract of asympomatic humans
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What is the natural reservoir of Corynepbacterium diphtheriae?
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Respiratory tract of asympomatic humans
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What is the morphology and staining of Corynepbacterium diphtheriae?
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Gram-positive
Club-shaped rod |
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What is the morphology and staining of Corynepbacterium diphtheriae?
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Gram-positive
Club-shaped rod |
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What is a selective media for Corynepbacterium diphtheriae?
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Potassium tellurite
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What is a selective media for Corynepbacterium diphtheriae?
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Potassium tellurite
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What is the mechanism by which Corynepbacterium diphtheriae causes disease?
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Toxin-mediated
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What is the natural reservoir of Corynepbacterium diphtheriae?
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Respiratory tract of asympomatic humans
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What is the mechanism by which Corynepbacterium diphtheriae causes disease?
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Toxin-mediated
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What is the morphology and staining of Corynepbacterium diphtheriae?
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Gram-positive
Club-shaped rod |
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What is the mechanism by which the Corynepbacterium diphtheriae toxin causes disease?
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Ribosylation of EF2--> inhibition of host protein synthesis
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What is the mechanism by which the Corynepbacterium diphtheriae toxin causes disease?
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Ribosylation of EF2--> inhibition of host protein synthesis
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What is a selective media for Corynepbacterium diphtheriae?
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Potassium tellurite
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What is the trigger for translocation of the Corynepbacterium diphtheriae toxin?
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Acidic pH within the lysosome
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What is the trigger for translocation of the Corynepbacterium diphtheriae toxin?
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Acidic pH within the lysosome
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What is the mechanism by which Corynepbacterium diphtheriae causes disease?
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Toxin-mediated
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What is the structure of the Corynepbacterium diphtheriae toxin?
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AB toxin
B subunit Binds A subunit Acts |
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What is the structure of the Corynepbacterium diphtheriae toxin?
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AB toxin
B subunit Binds A subunit Acts |
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What element is key to the expression of Corynepbacterium diphtheriae?
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Iron; if it's low, expression is turned on
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What is the mechanism by which the Corynepbacterium diphtheriae toxin causes disease?
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Ribosylation of EF2--> inhibition of host protein synthesis
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What element is key to the expression of Corynepbacterium diphtheriae?
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Iron; if it's low, expression is turned on
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What is the mechanism of expression of the Corynepbacterium diphtheriae toxin?
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Derepression or transcription when iron is low
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What is the trigger for translocation of the Corynepbacterium diphtheriae toxin?
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Acidic pH within the lysosome
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What is the mechanism of expression of the Corynepbacterium diphtheriae toxin?
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Derepression or transcription when iron is low
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What is the structure of the Corynepbacterium diphtheriae toxin?
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AB toxin
B subunit Binds A subunit Acts |
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What is the source of the Corynepbacterium diphtheriae toxin?
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Bacteroiphage
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What is the source of the Corynepbacterium diphtheriae toxin?
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Bacteroiphage
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What element is key to the expression of Corynepbacterium diphtheriae?
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Iron; if it's low, expression is turned on
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What is the mechanism of expression of the Corynepbacterium diphtheriae toxin?
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Derepression or transcription when iron is low
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What is the source of the Corynepbacterium diphtheriae toxin?
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Bacteroiphage
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Are all strains of Corynepbacterium diphtheriae toxic?
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NO!
They need to be infected by a bacteriaphage in order to become toxic. |
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Are all strains of Corynepbacterium diphtheriae toxic?
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NO!
They need to be infected by a bacteriaphage in order to become toxic. |
