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11 Cards in this Set
- Front
- Back
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Corynebacteria are what kind of bacteria
gm? spores? aerobes? |
gam + rods
aerobes no spores |
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what is the pathogenesis of corynebacteria
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human - respiratory droplet - human - bacterial growth in throat - local inflammation - pseudomembrane (if edema - maybe death
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systemic symptoms caused by corynebacteria are caused by
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exotoxin
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how does the the diptheria toxin work
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toxin binds membrane through B domain - toxin is endocytosed - A domain enters cytoplasm and blocks protien synthesis
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how does the A domain of the diptheria toxin block protein synthesis
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adenosine diphosphate ribosylation of EF2 (an enzyme involved in peptide bond formaiton on ribosome
p.aerugo also has exotoxin which influences EF2 |
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in diptheria - does the bacteria disseminate
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no - but the toxin spreads
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chinese letters
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corynebacterium diptheriae shows disordered growth while normal diptheroids which inhabit our skin and throat show ordered growth
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what is the role of temperate bacteriophage in Diptheria
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lysognic bacteriophage has gene for toxin (conversion)
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definitive diagnosis of diptheria depends on
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demonstration of toxin products in throat swab
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what is the treatment for diptheriae
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immediate hourse antitoxin or human antitoxin
since disease is caused by toxin the vaccine is a toxoid |
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if a person has contact with someone with diptheria then that person should be immunized and treated with
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penecillin
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