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15 Cards in this Set
- Front
- Back
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Betamethasone
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Long-acting glucocorticoid (3-5hrs)
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Dexmethasone (several formulations)
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Long-acting glucocorticoids (3-5hrs).
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Hydrocortisone (cortisol)
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Shortest half life glucocorticoids (0.5-1 hrs)
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Cortisone
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Shortest 1/2 life (0.5-1hrs)
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Methylprednisolone, prednisolone.
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Intermediate acting glucocorticoids (2-4 hrs).
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Prednisone
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Intermediate acting glucocorticoid (2-4 hrs).
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Triamcinolone
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Intermediate acting glucocorticoid (2-4 hrs).
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Mifepristone (RU-486)
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An antiglucocorticoid. At higher doses inhibits GR and secondarily increasing cortisol levels.
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Aldosterone
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Synthetic Mineralcorticoid 1/2 life (0.5-2hrs).
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Fludrocortisone acetate
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A synthetic mineralcorticoid 1/2 life 2-4hrs.
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Aminoglutethimide
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An adrenal steroid inhibitor (inhibits CYPA11A1-rate limiter).
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Metyrapone
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Adrenal steroid inhibitor (selective inhibitor of CYP11B1)
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Etomidate
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Adrenal steroid inhibitor (selective inhibitor of CYP11B1)
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Mitotane
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Adrenal steroid inhibitor. Used to tx inoperable adrenocortical cancers. Metabolically converted to a reactive acyl chloride by adrenal mitochondrial CYPs. Onset of axn takes weeks to months.
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Ketoconazole
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An antifungal which inhibits CYP17, at higher doses also inhibits CYP11A1
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