Cori Cycle And Pyruvate Dehydrogenase

Front 1

Cori Cycle

Back 1

In Muscle- pyruvate to lactate-NADH builds up from glycolysis and muscle hands lactate the H and leaves NAD
Liver-uses 6 atp and 2 nadh to make glucose

Front 2

Pentose Phosphate Shunt

Back 2

Generates Ribose-5-pi for nucleotide biosynthesis and NADPH- needed is fatty acid and steroid biosynthesis
takes glucose 6 phosphate and makes ribose and nadph

Front 3

Pentose Phosphate shunt
Oxidative Branch

Back 3

makes pentose-5-phosphate and 2 NADPH

Front 4

Pentose Phosphate shunt
Non-Oxidative Branch

Back 4

makes pentwhen run backward ose-5-phosphate

Front 5

PDH

Back 5

Pyruvate Dehydrogenase
Complex of 3 subunits with different enaymatic activitiy

takes Pyruvate through magic portal to form acetyl-CoA

Front 6

E1
E2
E3

Back 6

Pyruvate Dehydrogenase=
Dihydolipoyl transacetylase=
Dihydolipoyl dehydrogenase

Front 7

TPP

Back 7

Thiamine Pyrophoshate
reguired in action of PDH

Front 8

E1

Back 8

TPP becomes anion and attacks Pyruvate which loses a co2
TPP protonated to form hydrosyethyl TPP whichis oxidied to acety group and transfered to Lipoamide

Front 9

E2

Back 9

the now acetyl lipoamide gives acteyl grp. to CoA to make acetyl Co A

Front 10

E3

Back 10

Lipoamide gives 2e- to its FAD prothetic group and then to NAD

Front 11

Allosteric Regulation of PDH complex

Back 11

Inhibited=High energy sources, acetyl CoA, NADH, ATP
Stimulated=low energy sources, AMP, NAD, CoA

Front 12

PDH

Back 12

less active=pi, high energy signals, acetyl CoA, NADH, ATP

more active=depi, low energy sources, AMP, NAD, CoA