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22 Cards in this Set
- Front
- Back
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Distribution of Copper is around
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50-120mg
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The two oxidative forms of copper are
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Cu+ (cupro) and Cu++ (cupri) can transfer to each other
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Cu has 2 stable isotopes
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Cu63 and Cu65
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Cu Absorbtion ranges from
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around 12% (with high intake) to around 50% with low intakes
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typical intake of Cu is around
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1.2-1.7 mg/day
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low concentration of Cu is abosrbed via
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active transport
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high concentration of Cu is abosorbed via
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passive diffusion
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to inhibit Cu aborbtion
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Zinc, Fiber, and Sulfur, high luminal conc of Cu
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Zn inhibits absorbtion by
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inducing the systhesis of metallothionein for which Cu has stronger affinity
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Metallothionein acts as a ______ ____ when Cu intake is excessive
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detoxifying agent.
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Sulfur inhibits Cu by
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forming complexes with Cu and increasing fecal excretion
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Cu is transported with
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albumin and transcuperin
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Cu is excreted primarily via
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bile into intestine and out
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Food sources of Cu include
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organ meats, shellfish, whole grains and legumes
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Cu deficiency, is rare but can lead to
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anemia, bone mieralization, arterial desiease and myocardial disease, loss of pigmentation
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Cu deficiency can occur in infants fed
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poor breast milk, a
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Cu toxicity is rare and occures
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with intake of 200-500 times normal
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Genetic Copper deficiency is known as
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Menkes disease (inpaired transfer of Cu from mucosal into blood) FATAL
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genetic copper excess is known as
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Wilsons diease (impaired excresion)
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Ceruloplasmin- Ferroxidase I is a
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transporter of Cu and an oxidatice enzyme for metal oxidation
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Copper containing enzymes
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superoxide dismutase, cytochrome C oxidase, amine oxidases
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main enzyme for catabolism of monoamine is
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dopamine monooxygenase
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