Copper

Front 1

Presence of Copper in blood was first recognised in

Back 1

1875

Front 2

Found that traces of copper are essential for HB formation

Back 2

Hart and Elvehjem

Front 3

Adult body contains

Back 3

80g copper

Front 4

Highest conc of Cu is found in ____ followed by ____,___,____ and_____

Back 4

Liver brain heart kidney and muscles

Front 5

In _____ and at _____ the conc of Cu is much high but decreases during _____ year

Back 5

Foetus , birth , first

Front 6

Cu is absorbed in

Back 6

Small intestine

Front 7

In Small intestine Cu ions are bound to _____

Back 7

Metallothionein

Front 8

Cu level in ____ regulate cu level in intestine

Back 8

Mucosal cells

Front 9

Net abs of cu varies from

Back 9

25-60%

Front 10

% of cu abs ____ with _____ intake

Back 10

Decreases , increased

Front 11

About ___ % cu in blood plasma is bound as ___ complex known as _____

Back 11

95 , protein , ceruloplasmin

Front 12

_____ also act as an enzyme to erythrocyte forming cell in bone marrow

Back 12

Ceruloplasmin

Front 13

___% of cu is loosely bound in ___ and other proteins

Back 13

5 , albumin

Front 14

Cu is transported from blood in the blood to other tissue 1° bound to ____

Back 14

Albumin

Front 15

In ______ copper binds to metallothionein which serves as a ____ form for Cu

Back 15

Liver , storage

Front 16

Cu is trans from liver to other cells via

Back 16

Plasma

Front 17

Cu is transported from liver as a ___ which is major route of ____ of Cu

Back 17

Bile , Excretion

Front 18

Once Cu is in ____ cu becomes part of pool that may be ____ or ____ depending on need of cu

Back 18

Gastro intestinal tract , reabsorbed or excreted.

Front 19

Small amount of Cu is also excreted via

Back 19

Urine , sweat , menstrual blood

Front 20

Cu helps in formation of ______ by transporting Fe in transferring for ___ synthesis

Back 20

Hb , Hb

Front 21

Cu is required in many physiological function like (6)

Back 21

Erythropoiesis , skeletal mineralisation , CT formn , myelin formn , melanin pigment sun , oxid. Phosphorylation.

Front 22

________ enzyme which is _______ is required for oxidation of fatty acids

Back 22

Butyryl coenzyme , dehydrogenase

Front 23

_______ is required for melanin pigment formation

Back 23

Tyrosinase

Front 24

_ is required for purine metabolism and also in ___ system for energy production

Back 24

Uricase

Front 25

Several Cu containing protein such as____ and ____ help to protect against toxic effects of oxygen

Back 25

Hepatocuperin and erthrocuperin

Front 26

___ may result from deranged iron metabolism

Back 26

Anemia

Front 27

Deficiency signs of cu include (4)

Back 27

Anemia vascular comp osteoporosis neurological manifestations

Front 28

Decrease in _____ leads to diminished collagen and ____ cross linking.

Back 28

Lysl oxidase , elastin

Front 29

Low blood level of cu is observed in _____ , ____ syndrome and ____

Back 29

Kwashiorkar , nephritic syndrome and sprue.

Front 30

_____ is a malabsorption disease commonly found in tropical area marked with abnormal flattening of ____ and inflammation of the lining of _____ intestine

Back 30

Sprue , villi , small

Front 31

Low serum can also lead to _____ syndrome

Back 31

Menke kinky hair syndrome

Front 32

Menke kinky hair syndrome is a condition characterised by (6)

Back 32

slow growth , degeneration of brain tissue , hypothermia , seizures , defective arterial wall and depigmentation of skin

Front 33

Menke kinky hair syndrome results from ______ and ______ of cu and increased ______ of cu through urine

Back 33

Defective absorption , abnormal transport , increased excretion

Front 34

____ is a poor animal source of cu

Back 34

Milk

Front 35

______ , _______ and _____& are good plant sources of cu

Back 35

Legumes (soyabean) , oilseeds (sunflower , sesame ) , nuts (almonds)

Front 36

_____ are good animal sources of copper

Back 36

Seafood - oysters , crabs , lobsters , organ meats

Front 37

______ & ______ are fair plant sources of cu

Back 37

Whole grains and fruits & vegetable

Front 38

______ are fair animal sources of cu

Back 38

Other meats

Front 39

Excessive cu is toxic and seen in rare heredity condition called

Back 39

Wilson's disease

Front 40

In Wilson's disease body fails to excereate excess cu leading to accumalation on _ , _ , _ , _

Back 40

Liver , brain , kidney , cornea of eye

Front 41

Exceess of cu nay lead to _ ,_ , _____disorders

Back 41

Hepatitis, renal malfunction , neurological

Front 42

A pure veg diet may help to reduce cu toxicity due to low copper content of ____ and ____

Back 42

Fruits and vegetables