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9 Cards in this Set

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40 year old with a family history of lung disease presents with difficutly breathing. Genetic testing shows a PiZZ phenotype. There are high levels of elastase in the lung and low levels of alpha 1 antitrypsin. His lungs show enlargement and destruction of all structures distal to the terminal bronchi (acinus). Bullae are present. What is the diagnosis?
Panacinar Emphysema
50 year old heavy smoker presents with difficuty breathing. There are high levels of elastase in the lung and low levels of alpha 1 antitrypsin. His lungs show enlargement and destruction of respiratory bronchioles (proximal to alveoli) especially in the upper lobes of the lung. What is the diagnosis?
centriacinar emphysema
18 year old college freshman was tackled in a football game and suddenly could not breath. . There are high levels of elastase in the lung and low levels of alpha 1 antitrypsin. His lungs show enlargement and destruction of distal alveoli. What is the diagnosis?
paraseptal emphysema
50 year old male smoker presents who lives in a Latvia (cold) next to a power plant (pollutants) presents with a 3 year history of coughing up sputum which has been present on most days for the last 3 months. Analasis of his bronchii and small airways shows an increase in size and number of goblet cells and mucus producing glands in the epithelial lining. INFLAMMATION & fibrosis of the bronchii & small airways are also present. Lately he has developed complications of lung congestion & right ventricular hypertrophy. His sputum cultures out bacteria. What is the diagnosis?
Chronic bronchitis
Lungs were examined on a 16 year old who was killed in an LA (environmental pollutants) shooting. Examination shows inflammation of the bronchioles.
Besides pollutants what could cause the inflammation.
CHRONIC BRONCHIOLITIS
Viral infection
A 20-year-old female with a history of exzema & allergies and high IgE levels in the blood had sudden onset of wheezing with shortness of breath after exposure to ragweed. She had a history of similar previous episodes and a family history. Despite emergency treatment, she died the same day. On autopsy her lungs show mucus plugs (Curschmanns spirals) with a PREDOMINANCE OF EOSINOPHILS with Charcot Leyden crystals derived from plasma membrane of the eosinophil, CD4+ lymphocytes, aggregates of columnar cells (Creole bodies), and sloughed ciliated cells. There is also a THICKENING of airway BASEMENT MEMBRANE. What is the diagnosis?
BRONCHIAL ASTHMA
12 year old developes necrotizing pneumonitis after aspirating a peanut. He has foul smelling sputum & dilation of bronchial tree PROXIMAL to terminal bronchioles. What is the diagnosis? What are possible other causes for this disease
BRONCHIECTASIS
Tumor or cytic fibrosis
What lymphocyte type is associated with asthma
CD4+
What lymphocyte type is associated with COPD
CD8+