Reading...
Play button
Play button
Use LEFT and RIGHT arrow keys to navigate between flashcards;
Use UP and DOWN arrow keys to flip the card;
H to show hint;
A reads text to speech;
38 Cards in this Set
- Front
- Back
|
Define: Extracellular matrix
|
fibers + ground substance
|
|
|
What is: Type 1 Collagen
|
main type of connective tissue, found in skin, bone, tendon, ligaments
|
|
|
What is: Type 2 Collagen
|
Cartilage
|
|
|
What is: Type 3 Collagen
|
Reticular fibers
|
|
|
What is: Type 4 Collagen
|
basement membrane
|
|
|
What is: Type 7 Collagen
|
Connection of basement membrane to ECM
|
|
|
What do Matrix metalloproteases (MMPs) do?
|
Break down damaged collagen fibers
|
|
|
Scars & Keloids are a result of?
|
too much connective tissue (collagen)
|
|
|
List 3 components of all connective tissue
|
Made up of cells + EMC (ground substance and fibers)
|
|
|
What is ground substance?
|
Made up of GAGs (glycosaminoglycans) such as hyaluronic acid. Provides a flexible gel for extracellular matrix. Especially important in joints.
|
|
|
What are the two main types of fibers in connective tissue?
|
Collagen (includes reticulin) and elastin
|
|
|
What is elastin?
|
Fibers that can stretch. Primairly found in lungs, aorta, blood vessels.
|
|
|
What is collagen?
|
Main fiber found in supporting tissues. Provides tensile strength. You need to know 5 types!
|
|
|
What is reticular fibers?
|
Type 3 collagen, found in liver, bone marrow, etc, mostly produced by fibroblasts
|
|
|
What is cirrhosis?
|
damage to liver reticular fibers due to inflamation, reticular fibers are replaced with other collagen
|
|
|
Decribe the structure of elastin
|
elastin core + fibrilin (fibrilin very important to functional elastin)
|
|
|
What is Marfan syndrome?
|
Messed up fibrilin = messed up elastin
Symptoms: long limbs, aortic problems |
|
|
What do fibroblasts do?
|
Synthesize fibers and ground substance
|
|
|
What do mast cells do?
|
Release granuals of histamine and heparin
|
|
|
What does heparin do?
|
Anticoagulant
|
|
|
What does histamine do?
|
Increase contraction of vessels, increase vascular permiability, and mucos production
|
|
|
What is anaphylaxis?
|
Too much histamine is released, drop in BP (vasodialation), airway constriction
|
|
|
What does a macrophage do?
|
phagocytic, digestive, secretory functions
|
|
|
What do plasma cells do?
|
Antibody formation
|
|
|
What are the types of connective tissue?
|
Desnse (regular, irregualr), loose, adipose
|
|
|
Describe key features of loose connective tissue
|
Low in fibers, high in cells, high in ground substance
Found beneath epithelia |
|
|
Describe key features of dense regular connective tissue
|
High in fibers, low in cells, very low in ground substance
Foudn in ligaments and tendons |
|
|
Decribe key features of dense irregular conncetive tissue
|
High in cells and fibers, low in ground substance
Found in deeper layers of GI and skin |
|
|
What is cirrhosis?
|
damage to liver reticular fibers due to inflamation, reticular fibers are replaced with other collagen
|
|
|
Decribe the structure of elastin
|
elastin core + fibrilin (fibrilin very important to functional elastin)
|
|
|
What is Marfan syndrome?
|
Messed up fibrilin = messed up elastin
Symptoms: long limbs, aortic problems |
|
|
What do fibroblasts do?
|
Synthesize fibers and ground substance
|
|
|
What do mast cells do?
|
Release granuals of histamine and heparin
|
|
|
What is mesoderm?
|
The embrological tissue that CT develops from
|
|
|
What is mesenchymal tissue?
|
The CT that develops from mesoderm in adults
|
|
|
What is mucous tissue?
|
The CT that develops from mesoderm in the umbilical cord
|
|
|
What is white adipose tissue?
|
Fat cells in adults
|
|
|
What is brown adipose tissue?
|
Fat cells primarily in kids that produce heat
|
