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38 Cards in this Set

  • Front
  • Back
Define: Extracellular matrix
fibers + ground substance
What is: Type 1 Collagen
main type of connective tissue, found in skin, bone, tendon, ligaments
What is: Type 2 Collagen
Cartilage
What is: Type 3 Collagen
Reticular fibers
What is: Type 4 Collagen
basement membrane
What is: Type 7 Collagen
Connection of basement membrane to ECM
What do Matrix metalloproteases (MMPs) do?
Break down damaged collagen fibers
Scars & Keloids are a result of?
too much connective tissue (collagen)
List 3 components of all connective tissue
Made up of cells + EMC (ground substance and fibers)
What is ground substance?
Made up of GAGs (glycosaminoglycans) such as hyaluronic acid. Provides a flexible gel for extracellular matrix. Especially important in joints.
What are the two main types of fibers in connective tissue?
Collagen (includes reticulin) and elastin
What is elastin?
Fibers that can stretch. Primairly found in lungs, aorta, blood vessels.
What is collagen?
Main fiber found in supporting tissues. Provides tensile strength. You need to know 5 types!
What is reticular fibers?
Type 3 collagen, found in liver, bone marrow, etc, mostly produced by fibroblasts
What is cirrhosis?
damage to liver reticular fibers due to inflamation, reticular fibers are replaced with other collagen
Decribe the structure of elastin
elastin core + fibrilin (fibrilin very important to functional elastin)
What is Marfan syndrome?
Messed up fibrilin = messed up elastin
Symptoms: long limbs, aortic problems
What do fibroblasts do?
Synthesize fibers and ground substance
What do mast cells do?
Release granuals of histamine and heparin
What does heparin do?
Anticoagulant
What does histamine do?
Increase contraction of vessels, increase vascular permiability, and mucos production
What is anaphylaxis?
Too much histamine is released, drop in BP (vasodialation), airway constriction
What does a macrophage do?
phagocytic, digestive, secretory functions
What do plasma cells do?
Antibody formation
What are the types of connective tissue?
Desnse (regular, irregualr), loose, adipose
Describe key features of loose connective tissue
Low in fibers, high in cells, high in ground substance
Found beneath epithelia
Describe key features of dense regular connective tissue
High in fibers, low in cells, very low in ground substance
Foudn in ligaments and tendons
Decribe key features of dense irregular conncetive tissue
High in cells and fibers, low in ground substance
Found in deeper layers of GI and skin
What is cirrhosis?
damage to liver reticular fibers due to inflamation, reticular fibers are replaced with other collagen
Decribe the structure of elastin
elastin core + fibrilin (fibrilin very important to functional elastin)
What is Marfan syndrome?
Messed up fibrilin = messed up elastin
Symptoms: long limbs, aortic problems
What do fibroblasts do?
Synthesize fibers and ground substance
What do mast cells do?
Release granuals of histamine and heparin
What is mesoderm?
The embrological tissue that CT develops from
What is mesenchymal tissue?
The CT that develops from mesoderm in adults
What is mucous tissue?
The CT that develops from mesoderm in the umbilical cord
What is white adipose tissue?
Fat cells in adults
What is brown adipose tissue?
Fat cells primarily in kids that produce heat