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11 Cards in this Set
- Front
- Back
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A connective tissue disease characterized by muscle inflammation, main symptom is proximal muscle weakness
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polymyositis and dermatomyositis
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Four classic rashes of dermatomyositis?
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Gottron's Papules, Heliotrope Rash,
Shawl Sign, Mechanic's Hands |
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What is the hallmark feature of systemic sclerosis?
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scleroderma - thickened, hardened skin
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Hallmark features of Sjogren's Syndrome?
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diminished lacrimal and salivary gland function, which causes xeropthalmia (dry eyes) and xerostomia (dry mouth)
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What malignancy is Sjorgren's syndrome associated with?
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Non-Hodgkin's lymphoma. Lifetime risk is 5% (16-55 fold increased compared to general population)
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What is one specific entity of an overlap connective tissue syndrome?
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Mixed Connective Tissue Disease (MCTD)
- may have features of scleroderma, SLE, and myositis |
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What autoantibody is associated with Mixed Connective Tissue Disease?
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anti-RNP antibody
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Is positive anti-nuclear antibody (ANA) necessarily associated with disease?
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No, it's present in 3-5% of the normal population
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What are some extractable nuclear antidobies, other antibodies, and complement tests associated with systemic lupus erythematus?
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ANA, anti-dsDNA, ENA (Anti-Ro, La, Sm, RNP), low complements (C3, C4)
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Which autoantibody may give an indication of disease activity in SLE?
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anti-double stranded DNA
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What are two reasons Lupus anticoagulant (LAC) is a misnomer?
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1. it does not only occur in Lupus
2. it actually causes clotting |
