Reading...
Play button
Play button
Use LEFT and RIGHT arrow keys to navigate between flashcards;
Use UP and DOWN arrow keys to flip the card;
H to show hint;
A reads text to speech;
27 Cards in this Set
- Front
- Back
|
_______ are autoimmune disorders that cause chronic pain, loss of function, and crippling and have a high economic cost and social cost
|
Connective tissue disorders
|
|
|
Not autoimmume
Not systemtic "wear and tear" Joints lose cartilage and rub on each other May have bone spurs |
Pathophysiology of Osteoarthritis
|
|
|
Early stage of Osteoarthritis
|
joint pain and stiffness that is relieved with rest
|
|
|
Late stage of Osteoarthritis
|
pain with minimal motion and even at rest
|
|
|
Types of Analgesics
|
Tylenol
ASA NSAIDS (cox1 and cox2) Cortizone injection |
|
|
Most common joint replacement surgery
May last up to 20 years Last resort |
Total hip
|
|
|
Chronic, progressive systematic, inflammatory autoimmune disease
Usually feel better with activity Normally bilarteral and symmetric (equal on both sides) |
Rheumatoid Arthritis
|
|
|
Often associated with RA
|
Sjogrens Syndrome
Feltys Syndrome Caplan Syndrome |
|
|
Causes dry eyes, mouth and vagina
- then causes vision problems and cavities |
Sjogrens Syndrome
|
|
|
Leucopenia, enlarged liver and spleen
- decreased WBC - Immunocompromised |
Feltys Syndrome
|
|
|
Nodules in the lungs
|
Caplan Syndrome
|
|
|
0-39 is normal
- measures for unusual antibodies of immunoglobin (g) and (m) IgG, IgM |
RF - Rheumatoid Factor
|
|
|
Measures the titer of unual antibodies that can destroy cells
- is a value higher than 1:8 |
ANA or FANA - Antinuclear Antibody Titer
|
|
|
Looks for inflammation or infection
- 0-20 is ok - 20-40 mild - 40-70 moderate - 70-150 severe |
ESR - Erthrocyte Sedimentation Rate or Sed Rate
|
|
|
0.8 to 3.1 is normal
Measureas inflammation |
CRP - C-Reactive Protein
|
|
|
Ibuprofen
Celebrex Salicylates (aspirin) |
NSAIDS
|
|
|
Common side effect of NSAIDS
|
Tinnitis- ringing in the ears
|
|
|
Plagueril
Sulfasalazine Minocycline |
Disease Modifying Antiheumatic Drugs (DMARDS)
|
|
|
Takes 4 to 6 weeks to work
side effects include decreased WBC and platelets and increased enzymes and creatine NO ALCOHOL Causes major birth defects |
Methotrexate
|
|
|
Bilogical Respnse Modifier
- stimulates or restores the ability of the immune system to fight arthritis - Given as single IV infusion every 2 to 8 weeks (using the lease amount possible) - Can cause a sever reaction |
Remicade
|
|
|
Prednisone
Medrol - may cause: weight gain, decreased immune system, edema, insomnia, decreased healing, increased glucose level, *moon face*, think skin, and *decreased bone density* - no good for long term treatment |
Glucocorticoids or steroids
|
|
|
Classification of Lupus
- Effects the only the skin - will have discoid (coinlike) leasions or scarring evident on the skin - especiall when exposed to sunlight, vutterfly rash, and alopecia |
DLE- Discoid Lupus Erythematosus
|
|
|
Classification of Lupus
- Has systemic effects - Chronic and progressive - Causes major body organs and systems to fail - Can have periods of remissions and exacerbations (flare-ups) - Kidney failure is the leading cause of death - Likes to pick on one organ - Will have decreased urine output, increased BUN and creating, and will be SOB |
SLE - Systemic Lupus Erythematosus
|
|
|
- Hardening of the skin
- Chronic connective tissue disease - Patients do not respond well to steroids or immunosuppressants - Will have a very tight face from lose of elasticity in the connective tissue - Skill will be taut, skiny, and clear of wrinkles - then the skin hardens and thickens - may effect GI, cardiac, pulmonary, and renal systems |
Progressive Systemic Scleroderma (PSS)
|
|
|
Systemic disease which urate crystals deposit in the joints causing inflammation
Meds used: -NSAIDS and Colchicine for acute - Allopurinol and Probenecid for chronic - Aspirin and diurectis should be avoided Diet: limit soda and drink lots of water |
Gout
|
|
|
Most common form of gout
- results from one of several errors of metabolism - causing an end product of uric acid excreted to the kidneys - When the uric acid excededs the bodies ability to secrete it, it is deposited in the synovium (joints) |
Primary Gout
|
|
|
Chronic pain syndrome
Not inflammatory disease Has specific "trigger points" Can be very sensitive to pain May also have Chronic Fatigue Syndrome and often become depressed and anxious No diagnostic test |
Fribromyalgia (FMS)
|
