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24 Cards in this Set

  • Front
  • Back
Functions of CT
-structural support
-medium for exchange
-defense/protection
What's CT made of
-extracell matrix:
ground subst.,extracell fibers,tissue fluid
-Cells
2 types of CT
Loose connective/dense connective
LCT
-made of fibers=reticular/collagen/elastic
-ground subst=for H2O diffusion,O2,CO2, nutrients
-lots of cells:
fibroblasts/macrophage/leuko/adipose/mast
DCT
-made of dense fibers
-has fibrobblasts
-makes=tendons/ligaments/aponeuroses (all have coll type 1)
Collagen
-most abundant
-flexible
-stains pink w/ eosin dye
-fiber->fibrile->collagen
Type 1 collagen
in fibriles,fibers,bundles
-dentin
-tendons
-ligaments
-bone
Type 2
just fibriles
-elastic cartilage
-hyaline cartilage
Type 3
fibriles & reticular fibers
-lymph
-spleen
-organs
Type 4
filaments
-BL
Type 5
-placenta
Coll synth.
in RER:
preprocoll->signal cut->procoll->hydroxylation by proline & lysine residues->now its glycosylated & procol forms trip helix-> exported out of golgi->tropocoll 2 alpha,alpha & 1 alpha 2 chain
Reticular fibers
-support & framework for tissues & organs
-type 3
-in nerves/bv's/muscle/lymph/rd bone marrow/endocrine glnds
Elastic fibers
-elastisity
-in EC matrix
-made of proteoglycans & glycoprots (rich in pro &gly)
-in LCT/aorta/ligamentum flavae
Ground Substance
-allows for diff of nutrients & O2
-inc H2O content
made of:
proteoglycans that are made from GAG,& glycoprots
these form polycacc chains
What does GAG do?
-sulfation of sugar residues->causes charge->allows basic dye stains->attracts H2O->hydrates gel->allows diff of H2O & sol subts
7 types of GAG's
based on degree of sulfation & type of sugar residue
-2 chondrotins
-2 heparans
-1 hydronic acid
-1 keratin
-1 dermatin
Fibroblast cells
-fixed
-makes & destroys collagen,grnd subst.,elastic & retic fibers
-2 forms inactive & active
active= in cytoplasm,lots of it,lots of RER,irreg branched
inactive= small,spindle shape,les RER
Macrophage
-fixed
-from monocytes
-diapedesis
-have lysosomes/lots of RER/big golgi/lots of MT's & MF's
function:
-phago/pino
-activate imm sys.
-resist inf.
Mast cell
-from BM
-cyto plasm has lots of granules is metachromatic
release:
heparin-anticoag
histamine-vasodil
leukotriene-slow cont of sm. musc.
Immediate hypersensitivity rxns
after 1st exp. to Ag->IgE binds to its recept. on mast cell=sensitization
-after 2nd exp->same Ag binds to IgE on mast cell->degranulation->releases->histamine,leukotrines
Plasma cells
make Abs to certain Ags
migrate to CT when infect.
Mesenchyme
-makes lots of cells
-makes myofibroblasts for wound repair
Adipose
brown-fetal gone after 10 yoa,multilocular
white-unilocular
-provides energy
-insulates
-lots of retic fibers & bld vessels