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13 Cards in this Set
- Front
- Back
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In mothers, how does primary CMV present?
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Mild illness, hepatitis, fever, atypical lymphocytosis.
Often asymptomatic. |
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What happens to CMV after the initial infection?
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Remains latent in the mother.
Can be reactivated around pregancy. |
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Which is more dangerous to the foetus - primary CMV or reactivated CMV?
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Primary.
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How can CMV be transmitted to the baby?
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In utero: transplacentally
At birth: maternal genital secretions After birth: breast milk |
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What is the main problem associated with congenital CMV?
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Causes sensorineural hearing loss.
Is responsible for 10 - 30% of childhood hearing loss. |
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What are the clinical features of severe CMV infection?
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IUGR
Hepatosplenomegaly Hepatitis Aneamia, thrombocytopenia Pneumonitis Microcephaly, encephalitis, cerebral calcification, chorioretinitis SNHL Cerebral palsy, intellectual disability, epilepsy, vision impairment |
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How is CMV infection diagnosed?
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PCR of amniotic fluid at 18 weeks gestation.
OR Positive urine or saliva culture collected during first three weeks of life. |
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In mothers, how does parvovirus present?
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Most commonly as "slapped cheek".
Mild URTI Petechial or purpuric rash Arthritis in adults Often asymptomatic |
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When is the worst time to get parvovirus infection? (i.e. most dangerous to the foetus)
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First 20 weeks of gestation.
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What are the complications of parvovirus B19 infection?
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Foetal loss
Congenital abnormalities Hydrops fetalis |
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How is parvovirus B19 diagnosed?
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Serology and PCR.
IgM detectable within 1 - 3 weeks of exposure, up to 3 months. IgG may rise within 2 - 3 weeks of exposure. |
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What is the risk of exposure to parvovirus B19 in adult women?
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60% of women are immune.
Exposure from an affected child (50%). Exposure in childcare and primary school teachers (20 - 30%). Overall risk of exposure: 10 - 20%. |
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How should suspected parvovirus B19 infection in the mother be managed?
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Test serology:
- seronegative: repeat in 2 weeks. If clear, no further monitoring. - seropositive: US at 1 - 2 week intervals for next 8 weeks checking for development of foetal hydrops. |
