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32 Cards in this Set
- Front
- Back
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C1
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binds occupied antibodies
activates C2, C4 |
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C2
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C2a+C4b = C3 convertase
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C3
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C3b = opsonization
C3a = inflammation C3bBb = C3 convertase |
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C4
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C2a+C4b = C3 convertase
C4b = opsonization C4b binds CR1 on neutrophils and macrophages (phagocytosis/kill) |
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C5 convertase
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C2a+C4b+C3b = C5 convertase
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C5,6
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C5 made by C2aC4bC3b, part of MAC
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C7
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Membrane insertion domain of MAC
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C8
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Transmembrane domain of MAC
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C9
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Pore components of MAC
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Factor B
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Factor Bb + C3b = C3 convertase (C3bBb)
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Factor D
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cleaves factor B to activate C3 convertase
B-> Ba, Bb (part of convertase) |
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Factor H
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Binds C3b-Factor I to deactivate C3b
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Factor I
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-converts C3b-->iC3b (more potent opsin)
-By converting C3b to iC3b, inactivates C3bBb |
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Factor P
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Stabilizes C3b, prevents factor H binding
-Also called PROPERDIN -stabilizes C3bBb |
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C3b
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-opsonization
-makes alternative pathway C3bBb -C5 convertase C2aC4bC3b |
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C5a
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cleavage product of C5 w/ chemotactics for neutrophils
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CR1
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(CD35)
-binds C3b/C4b (opsonins) -erythrocytes, granulocytes, mono/macrophages, B-cells, T-cells, follicular DC -promotes phagocytosis |
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CR2
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(CD21)
-binds C3dg -lowers activation threshold of B cells |
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CR3/CR4
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(integrins)
-binds iC3b -mono/macrophages, NK cells, granulocytes, follicular DC -promotes phagocytosis |
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C3a/C5a-R
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inflammatory response receptors, bind C3a/C5a
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DAF
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decay acceleration factor
-on cell membranes -binds C2/C4 to prevent C3 cleavage |
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MCP
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membrane cofactor protein (CD46)
-on cell membranes -binds C3b/C4b to cleave and inhibit opsonization -not present on RBC's |
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CD59
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Blocks membrane attack complex
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C1-INH
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plasma-located C1 inhibitor (prevents C2/C4 cleavage)
-prevents C3 cleavage |
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S protein
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plasma-located
-prevents MAC complex from binding host cells |
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C4,C3 low
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classical pathway overdrive
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C4 normal, C3 low
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alternative pathway active
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CH50, THC both zero
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inactive
-complement deficiency -loss of activity in vitro |
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Pyogenic infections
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Indicates poor opsonization/phagocytosis.
-deficiency in the C3 synthesis pathway |
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Neisseria infection
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Poor cell lysis
-occurs w/ deficiencies in MAC complex |
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C-reactive protein
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-produced in liver, induced by cytokines
-opsonizes bacteria, complement activator -predictor of myocardial events |
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Surfactant
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produced by type 2 pneumocytes, bind to microbes for phagocytosis
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