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8 Cards in this Set
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acute lymphocyte leukemia (ALL)
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MOST COMMON MALIGNANCY OF CHILDREN
produces an overabundance of lymphoblasts (immature lymphocytes) casues lymphadenopathy and impaired bone marrow funx (causes fatigues, thrombocytpenia (in later stage), increase recurrent infx) |
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Acure myelogenous Leukemia (AML)
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affects all ages, but occurrence peaks between ages 15-39
causes impaired bone marrow fnx (causes fatigues, thrombocytpenia (in later stage), increase recurrent infx) AUER RODS (red-staining, peroxidase positive needle-like structures; evidence of myeloid proliferation) are visualized in myeloblasts very fast to manifest--> can die in 6 monts after DX |
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chronic myleogenous Leukemia (CML)
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in 25-60 years old, peak in 30-40
casues impaired bone marrow inx associated wiht PHILADELPHIA CHROMOSOME (9:22) chromosomal translocation like bcr-abl fusion gene associated with Low LAP (leukocyte alkaline phosphatase) high LAP: wbc are function so in WBC are due to infx are not due to cancer Low LAP: increase in nonfunctional WBC due to leukemia takes years to manifest |
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chronic Lymphocytic leukemia (CLL)
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in >50 years old
males>females mature lymphocytes predominate cause lymphadenopthy and imparied BM fnx unusual variant is SEZARY SYNDROME ( Leukemia that results from untreated Mycosis Fungoides (Lymphoma) Mycosis fungoides: solid tumore in the skin, also called CUTANEOUS T CELL LYMPHOMA. the only Lymphoma that can cause leukemia (sezary syndrome) |
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Hairy cell leukemia
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mostly in middle-aged white males
hepatomegaly (rare) and SPLENOMEGALY (#1 SIGN) involves only B cells (that develop hair like projections) casues imparired BM funx (+) TRAP (TARTRATE -R-ACID PHOSPHATASE) and CD25 markers |
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Lymphomas
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solid tumor or neoplastic lymphocytes
ususlly dont produce symps untill large enoug to impinge other nearby organs |
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Hodgkin's dis
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Leukocytosis of PMNs
(+) reed-sternberg cells (separates from non-hodgkin) contiguous spread nodal involvment High # RS cells--> poor px 4 subtypes: 1. lymphocyte predominance ( lost RS, best Px) 2. nodular sclerosis (hald of cells are RS, more comom in females, MOST COMMON SUBTYPE) 3. Mixed cellularity( one half are RS cells, more in males) 4. lymphocyte depletions ( highest number of RS, worsl Px) |
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Non hodgkins lymphomas
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NO REED STERNBERB CELLS
widespread adenopathy (non contiguous spread= spread everywhere) hypercalcemia hepatosplenomegaly probably viral etiology ( EBV) associated wiht bcl-2 spereads to multiple different nodes NEUTOROCYTOSIS worst type of non-hodgkins lymphoma is BURKITTS LYMPHOMA (c-myc) |