Reading...
Play button
Play button
Use LEFT and RIGHT arrow keys to navigate between flashcards;
Use UP and DOWN arrow keys to flip the card;
H to show hint;
A reads text to speech;
17 Cards in this Set
- Front
- Back
|
SLE
|
type 2, 3
tests: screening: ANA DX: Anti-ds DNA, anti smith LE cell test, VDRL (false positive) Black women 4 types of nephropathy |
|
|
Mesangial dis (most common and mildest) : class II
|
transient proteinuria
PROLIFERATION OF MESANGIAL MATRIX AND MESSANGIAL CELLS |
|
|
focal proliferative nephritis: class III
|
proteinuria + hematuria, proliferation of mesangial cells and matrix, ENDOTHELIAL PROLIFERATION, FOCAL LESION
|
|
|
diffuse proliferative nephritis (most severe) class IV
|
nephrotic syndrome, gross hematuria, proliferation of mesangium +endothelium +EPITHELIUM +/- CRESCENT FORMATION, DIFFFUSE LESION, SUBENDOTHELIAL IMMUNE COMPLEX DEPOSITION, renal fail +HTN
|
|
|
Membranous glomerulonephropathy: class V
|
nephrotic syndrome, ENDOTHELIAL THICKENING, SUB EPITHLIAL COMPLEX DEPOSITS
|
|
|
Job's syndrome (phagocyte disorder)
|
deficient Gamma IFN
sinoplumonary infx, candidiasis, cold abscesses |
|
|
chediak Higaski syndrome (phagocyte dix)
|
impaired microtubles limiting WBC movement and use of granules
bacterial infx, viral infx, partial albinism |
|
|
chronic granulomatous diz (phago. dix)
|
deficient NADPH oxidase causing impaired resp. burst
granulomas, recurrent bact. & fungal infx, yellow NBT test |
|
|
brutons agammaglobulinemia (humoral Immunity)
|
No mature b cells
DIAD: reccurent severe pyogenic infx, severly low amt of ABS |
|
|
IGA deficiency (humoral Immunity)
|
igA plasma cells fail to develop
bact. infx of mucus membrane, possible anaplylaxis to transfused blood, redused IgA |
|
|
common variable immunodeficiency (humoral Immunity)
|
Abnormal b cell maturation
recurent pyogenic bact. infx, normal number of b cells, decreased level of Abs |
|
|
digeorge syndrome (thymic aplasia) (cell mediated imunity )
|
defect in the 3rd and 4th pharyngeal pouches results in development failure of thymus and parathyroids
deficits in T cells, recurrent viral, fungal, protozona infx, tetany, hypocalcemia |
|
|
chronic mucocutaneous candidiasis (cell mediated imunity )
|
tcells cant destroy candida albicans
chronic candidiaiss, normal t cells number |
|
|
Hyper IgM syndrome (cell mediated imunity )
|
inability of b cells to class switch from igm to igG ( loss of CD 40 ligand on Tcells)
severy recurrent pyogenc infx |
|
|
svere combined immunodef. (scid) ( b and t cell dix)
|
1; IL-2 receptor defect on CD4, CD8 or Tcell secondary messenger system defect, or defect in t cell ability to interact wiht APC's, or absence of adenosine deaminase resulting in increased dATP and decrease DNA production, or devective class I, II MHC
recurrent bacterial, viral, fungal, protozoal infx, low antibody levels, no lymph nodes, monst comonly pneumocyctis pneumonia |
|
|
Wiskott Aldrich syndrome ( b and t cell dix)
|
b cells not stimulated to make IgM (impaired intial response)
recurrent bact. infx (especiallty otits media), eczema, thrompcytopenia (low MPV), low igM levels |
|
|
ataxia telangiectasia ( b and t cell dix)
|
deficient DNA repair enzymes, resulting in t and b cell deficienceis
ataxia, telangiectasia, recurrent infx (especially sinopulmo), increased malignancy risk, low t cell numbers, igA deficiency |
