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31 Cards in this Set
- Front
- Back
- 3rd side (hint)
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t(9;22)
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Chronic Myelogenous Leukemia
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BCR-ABL
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t(8;14)
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Burkitt Lymphoma
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c-MYC-IgH
also t(8:2) or t(8:22) |
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t(15;17)
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Acute Promyelocytic Leukemia
(aka AML M3) |
PML-RARA
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del(5q) or del(7q)
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MDS
Therapy-related AML |
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What are the 4 cytogenetic abnormalities that confer a good prognosis in AML?
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t(8;21)
inv(16) or t(16;16) t(15;17) |
RUNX1-RUNX1T1
CBFB-MYH11 PML-RARA |
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Which molecular abnormalities confer a worse prognosis in AML?
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FLT3 ITD (internal tandem duplications)
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CEBPA
NPMI |
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What cytogenetic abnormality confers a bad prognosis in AML?
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t(12;21)
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TEL-AML1
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What are the 2 cytogenetic abnormalities that confer a good prognosis in ALL?
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t(12:21)
Hyperdiploidy (51-65 chromosomes) |
TEL-AML1
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What are the 3 cytogenetic abnormalities that confer a bad prognosis in ALL?
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t(9;22)
11q23 t(1;19) |
BCR-ABL
MLL |
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What cytogenetic abnormality confers a worse prognosis in CLL?
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Trisomy 12
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t(14;18)
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Follicular lymphoma
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BCL2-IgH
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t(11;18)
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MALT - resistant to H.pylori eradication
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Trisomy 3
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MALT - common
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t(4;11)
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Mantle Cell Lymphoma
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BCL1 (CyclinD1 is the product)
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Complex karyotype of monosomy 13
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Multiple Myeloma
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t(2;5)
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Atypical Large Cell Lymphoma
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ALK
also t(1;5) or t(1;2) or t(2;3) |
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t(3;14)
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DLBCL
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BCL6-IgH
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t(X;18)
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Synovial Sarcoma
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SSX1-SYT or SSX2-SYT
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t(X;17)(p11;q25)
der(17) |
Alveolar Soft Part Sarcoma
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ASPL-TFE3
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t(12;22)
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Clear Cell Sarcoma of Soft Parts
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EWSR1-ATF1 and EWSR1-CREB1
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t(1;13)
t(2;13) |
Alveolar Rhadbomyosarcoma
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PAX3-FKHR (now FOXO1)
PAX7-FKHR (now FOXO1) |
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del(11p15)
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Embryonal rhabdomyosarcoma
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t(11;22)(q24;q12)
t(21;22)(q12q12) t(7;22)(p22;q12) t(17;22)(q12;q12) t(2;22)(q33;q12) |
Ewing's/PNET
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t(11;22)(q24;q12) --> FLI1-EWS
t(21;22)(q12q12) --> ERG-EWS t(7;22)(p22;q12) --> ETV1-EWS t(17;22)(q12;q12) --> E1AF-EWS t(2;22)(q33;q12) --> FEV-EWS |
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t(11;22)
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Desmoplastic Small Round Blue Cell Tumor
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WT1-EWS
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t(9;22)
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Myxoid Chondrosarcoma
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t(12;15)
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Infantile/Congenital Fibrosarcoma
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ETV6-NTRK3
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t(12;17)
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Dermatofibrosarcoma Protuberans (DFSP)
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COL1-PDGFRB
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t(12;16)
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Myxoid/Round Cell Liposarcoma
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FUS-DDIT3 (aka TLS-CHOP)
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11p13
11p15.5 |
Wilm's Tumor
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WT1
WT2 |
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t(12;15)
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Congenital Mesoblastic Nephroma (cellular type)
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ETV6-NTRK3
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N-myc
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Neuroblastoma
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