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17 Cards in this Set

  • Front
  • Back
What category of polyps are found in FAP - Familial adenomatous polyposis
-adenomatous
-hamartomatous
adenomatous
What category of polyps are found in Peutz-Jeghers syndrome
-adenomatous
-hamartomatous
hamartomatous
What category of polyps are found in Juvenile polyposis syndrome
-adenomatous
-hamartomatous
hamartomatous
What category of polyps are found in MAP MYH-associated polyposis
-adenomatous
-hamartomatous
adenomatous

(this is the only autosomal ressive syndrome of the CRC syndromes)
found in Lynch Syndrome
-adenomatous
-hamartomatous
adenomatous
found in cowden syndrome
-adenomatous
-hamartomatous
hamartomatous
What gene is associated with Lynch Syndrome (HNPCC)
MMR
What gene is associated with FAP (familial adenomatous polyposis)
APC
What gene is associated with MAP (MYH-associated polyposis)
MYH
What gene is associated with Peutz-Jeghers Syndrome
STK11
What genes are associated with JPS (juvenile polyposis syndrome
SMAD4
BMPR1A
What gene is associated with Cowden syndrome?
PTEN
Which of the following cancer syndromes has
nearly 100% lifetime risk of colon cancer?
-FAP
-HNPCC (Lync)
-PH
-JP
-CS
-FAP
Shat prophylactic surgery is recommended in Lynch?
Remove uterus & ovaries after age 30 (when done with family) - do HRT
What genes is lynch caused by?
MMR - mismatch repair genes:
-MLH1 & MSH2
-MSH6
PMS2
If you have at least 10 cumulative colonic adenomas what would you test for?
APC & MYH
If you have very early onset CRC with just a few adenomas what would you test for?
Lynch (MSI/IHC)

If normal then
-Li-Fraumeni
-MAP
-AFAP