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57 Cards in this Set
- Front
- Back
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neuronal type of nicotinic antagonist
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ganglionic blockers
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muscle type of nicotinic antagonist
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neuromuscular blockers
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muscarinic antagonist are
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M1
M2 M3 |
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where do M1's mainly work on
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neurons
GI tract |
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where od M2's mainly work on
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heart
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where do M3's mainly work on
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smooth muscle
glands |
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muscaric antagonists will cause mydriasis or miosis
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mydriasis
will block miosis |
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have ---- vision w/ musc antag
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blurred
block accomadation |
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tacy/brady cardia w/ musc blockers
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tacy
cuz no muscarinic to slow down |
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how will musc antagonist cause flushing
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decreased sweating will lead to an increased temp
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bronchodilation/constriction w/ muscarinic antag
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bronchodilation
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incresed or decreased secretions
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decreased
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will there be increased or decreased GI motility
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decreased
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increased/decreased GI secretions
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decreased
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urine retention or incontinence w/ musc antag
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retention
decreased tone |
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cns actions w/ musc antag
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ataxia
hallucinations delirium coma |
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belladonna alkaloid
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atropine
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t/f
atropine is selective musc blocker |
t/f
nonselective |
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uses of atropine
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mydriasis
bradycardia GI hyperactivity Bronchodilation homatropine |
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how will atropine be used in bradycardia
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removes muscarinic block
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atropine give in gi hyperactivity why
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it slows down motility
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a derivative of atropine w/ a shorter duration
has OH group |
homatropine
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t/f
homatropine has a longer duration then atropine |
f
shorter |
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atropine overdose
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Dry as bone (decreased secretion)
Red as beet (flushing) Blind as bat (blockade of accomodation) Mad as Hatter (hallucinations, delirum) |
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atropine can cause fever in which population
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kids
no sweating, excessive temp |
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t/f
antidote for atropine is neostigmine |
f
physostigmine can't use neostigmine cuz it doesnt' get into the CNS so, it'll only work peripherally. you want it to work both peripherally and cns |
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why's use physostigmine
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cuz it's a Ache inhibitor, so there's ach and this will compete w/ the atropine
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scopolamine is a alkaloid know from which plant
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henbane shrub
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tx effects of scopolamine
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effective prophylaxis of motion sickness
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what will scoplamine cause in the eyes
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mydriasis
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scopolamine will enhance memory
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f
cause amnesia |
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t/f
scopolamine will cause cns depression |
t
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what type of sleep w/ scopolamine
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"twilight sleep"
will feel everything during sx |
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ipratropium/tiotropium is a ----- ammonium
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quaternary
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t/f
ipratropium/tiotropium crosses the bbb |
f
doesn't |
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route for tiotropium/ipatropium
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inhalation
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which has a lower paralytic effect tiotrop/ipa or atropine
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ipatropium/tiotropium
so, it doesn't paralyze the cilia |
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which has a longer duration tio or ipa
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tio
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receptors for tio
ipa |
tio: M1-M3
ipa: M1 and M3 |
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uses for tio/ipa
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COPD
Asthma |
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med's that selective for the bladder
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tolterodine
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tolterodine is used for an ---- bladder
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overactive
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s/e of tolterodine
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dry mouth
about 40% c/o |
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oxybutynin used for
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urinary incontinence
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s/e of oxybutynin
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dry mouth
dry eyes |
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benefits of transdermal formulation
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less effects on salivation and eyes
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solifenacin/darifenacin is selective for -----
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M3 antagonist
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solifenacin/darifenacin is more or less selective for bladder
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more
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t/f
w/ solifenacin/darifenacin however, you'll have more dry mouth and eye interactions |
f
less dry mouth and eye interactions |
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drug interactions w/ solifenacian
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CYP3A4
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drug interactions w/ darifenacin
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CYP3A4
CYP2D6 |
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this used for tremors in parkinson's
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benztropin
trihexyphenidyl |
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benztropin/trihexyphenidyl balance --- release
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DA
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does benztropin/trihexyphenidly stope the progression of parkinson's
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no
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benztropin/trihexyphenidly causes --- excitation
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CNS
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t/f
pirenzipine more effective than H2 blockers and PPI |
f
cuz it only blocks M1 and not the gastrin and M3 whereas the H2 and PPI stop the secretion of acid, pirenzipine only modifies it |
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what's pirenzipine selective for
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M1
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