Cology, Bb

Front 1

bb have ---- inhbition of cardiac B- receptors

Back 1

competitive

B1

Front 2

this competitive inhibition o f b1 receptors will decrease ----, and increase

Back 2

decrease CO

increase acute reflex TPR

Front 3

bb will impair --- tolerance

Back 3

exercise

Front 4

bb have block b1 that mediate ---- release

Back 4

renin

Front 5

blocking renin release will also block -----

Back 5

ang 2

Front 6

bb will also block--- receptors in the lungs

Back 6

b2

Front 7

blocking b2 in the lungs will decrease

Back 7

bronchial smooth muscles reelaxation

can lead to bronchospasm in asthma

Front 8

why's there impaired exercise tolerance w/ bb

Back 8

decrease co, decrease bl tissue O2 and glucose

Front 9

blockade of ---- b2 receptors will block ----- release

Back 9

presynaptic

NE

Front 10

bb will affect the cns by?

Back 10

decreasing SNS activity

Front 11

the more ----- soluable the more cns effects

Back 11

lipid

Front 12

bb can cause ---

Back 12

depression

Front 13

t/f

bb used durin pt's migraine

Back 13

f

used prophylactically to treat migraines

Front 14

bb will alter the ----reflex response

Back 14

baro

Front 15

differences in bb

Back 15

selectivity

metabolism

isa

membrane stabilizing activity

direct vasodilation

Front 16

metabolism of bb thru

Back 16

hepatic

renal

Front 17

t/f

bb has bad gi absorption

Back 17

f

good gi absorption

goes thru 1st pass

Front 18

t1/2 life of bb

Back 18

low

Front 19

--- soluable bb has poor absorption renally

Back 19

water

Front 20

isa:

inherant --- activity

how's this useful

Back 20

agonist

partial agonist useful w/ asthmatics, chf, bradycardia

Front 21

bb has ---- stabilizing activity

Back 21

membrane

Front 22

lidocaine has both antiarrhytmic and ----- activity

Back 22

anesthetic

Front 23

bb have -- anesthetic activity

Back 23

local

Front 24

bb have enchanced ------- activity

Back 24

anti arrhythmic

Front 25

membrane stability acitivty seen ---- therapeutic conc

Back 25

above

Front 26

bb inhibit -- channels and activity of ----

Back 26

Na

neurons

that's why: membrane stabilizing activity

Front 27

directe vasodilation of bb thru

Back 27

no production

alpha 1 antagonist

beta 2 agonist

ca entry blockade

k channel opening

antioxidant acitivity

Front 28

which nonselective has the most membrane stabilizing acivity

Back 28

propranolol

Front 29

which nonselective bb has he most lipid soluability

Back 29

penbutalol

propranolol

Front 30

which nonselective bb has the least lipid solubility

Back 30

nadolol

pindolol

sotolol

Front 31

which nonselective bb has mod lipid solubility

Back 31

timolol

Front 32

which nonselective will cause vivid dreams

Back 32

penbutolol and pindolol

cuz of high lipid solubility, will cross bbb

Front 33

which nonselective has the highest isa

Back 33

pindolol

Front 34

which nonselective has the least isa

Back 34

penbutolol

Front 35

selective b1 blockers w/ membrane stabilizing ability

Back 35

acetutolol

metoprolol (at high doses)

Front 36

selective b1 blockers w/ lipid solubility

Back 36

metoprolol

Front 37

3rd generation bb that are b1 selective

Back 37

betaxolol

nebivolol

Front 38

3rd gen bb w/ membrane stabilizing ability

Back 38

carvedilol

Front 39

3rd gen bb w/ mod bb solubility

Back 39

carvedilol

betaxolol

nebivolol

Front 40

3rd gen bb w/ low lipid solubility

Back 40

cartelol

labetalol

Front 41

when is bb a first line med

Back 41

angina

mi

a fib

Front 42

focus of htn according aha

Back 42

bp <130/80

Front 43

first line meds for htn

Back 43

acei

arb

thiazide like

ccb

(usu takes 2 drugs)

Front 44

bb used in uncomplicated ----

Back 44

htn

Front 45

bb used in htn used best in which pop of pts

Back 45

young pt

Front 46

why are bb best in young pts

Back 46

cuz of resting tachycardia

increase in catecholamines

increase in renin

Front 47

t/f

bb not useful in the elderly for htn

Back 47

f

still useful

Front 48

bb works best in high/low renin htn

Back 48

high

Front 49

which pop usu have high renin htn

Back 49

caucausians

Front 50

thru which receptors will bb decrease co and ang 2

Back 50

b1

Front 51

thru which receptors will bb decrease ne release

Back 51

b2

Front 52

t/f

bb works to decrease sns peripherally

Back 52

f

centrally

Front 53

bb have an altered ----

Back 53

baroreflex

Front 54

how will bb control glaucoma

Back 54

decrase aq humor production

Front 55

t/f

bb will increase outflow of aq humor

Back 55

f

Front 56

bb used in glaucoma

Back 56

timolol

betaxolol

cartelol

Front 57

bb used in migraines

Back 57

propranolol

timolol

Front 58

how do bb work in prophylactic use of migraines

Back 58

prevent vasodilation that cause migraines

Front 59

bb will decrease --- and severity of ha if used prophylactically

Back 59

frequency

severity

Front 60

bb used in hyper----

Back 60

thyroidism

Front 61

how will bb help w/ hyperthyroidism

Back 61

decrease symptoms

decrease conversion of t4 to t3 peripherally

Front 62

how can bb increase bp w/ hyperthyroidism

Back 62

when hr slowed the sv will increase

this will increase bp

Front 63

bb used in angina ---

Back 63

pectoris

Front 64

ischemia due to an increase in ---/---

Back 64

NE/EPI

Front 65

bb results when there's increased ---- or increased myocardial ----- beyond specific threshold

Back 65

HR

contractility

Front 66

ischemia associated w/

Back 66

activity

Front 67

how do bb relieve symptoms

Back 67

increase time to hr associated w/ angina

prolong time to reach threshold to symptoms

Front 68

why have exercise intolerance w/ bb

Back 68

prevents vasodilation in muscles/vessels/lungs

bb prevent increase in HR

Front 69

w/ acute mi which bb do you use

Back 69

ISA

Front 70

bb protect ischemic mycocardiam from ----

Back 70

NE/EPI

Front 71

bb protects from --- mi

Back 71

recurrent

Front 72

how do bb protect against mi

Back 72

decrease contractility

Front 73

bb decrease --- ---- and decrease workload

Back 73

O2 demand

decrease workload allows repair

Front 74

bb indicated for ------ arrhythmias

Back 74

supraventricular

Front 75

for supraventricular arrhythmias bb blocks --- node and --- transmission

Back 75

AV

slows

slows

slows contractions and increases filling and increase pumping

Front 76

why does the av node have a slower rate

Back 76

to allow time to contract

push blood out of ventricles

Front 77

bb extends --- period

why

Back 77

refractory (time where you can't generate action potential)

bb extends the refractory period to slow # of impulse that reach the AV node. . . gives timeto accomadate

Front 78

how do bb work w/ panic attacks

Back 78

works to eliminate s/s

Front 79

how do bb work in benign essential tremors

Back 79

block b2 receptor on skeletal muscle

Front 80

why are bb not used in parkinson's

Back 80

cuz tremors in parkinson's are central

bb work peripherally. . . golfers use

Front 81

bb used in benign essential ----

Back 81

tremors

Front 82

bb used in chf

Back 82

carvidilol

metoprolol

bisoprolol

nebivelol

Front 83

in hf bb will --- co, -- tpr, --- hr

Back 83

increase co

decrease tpr

decrease hr

Front 84

bb will initially worsen symptoms start w/ --- dose and---- slowly

Back 84

low

increase

Front 85

bb will --- qol of a pt and their ability to tolerate more ----

Back 85

increase

exertion

Front 86

bb cause broncho-----

Back 86

constriction

asthma exacerbation

1/3 of copd pts have brochospasm ci

Front 87

which bb would you use in asthmatic, copd

Back 87

b1 selective

Front 88

bb have cardio------ actions

Back 88

depressive

Front 89

bb have negative ---- and ---- actions

Back 89

inotropy

chronotropy

Front 90

neg inotropy lead to --- and ----

Back 90

fatigue

chf

Front 91

neg chronotropy lead to -----

Back 91

bradycardia

Front 92

bb can lead to --- block

Back 92

av

1st, 2nd, 3rd degree heart block

Front 93

bb will separate rate in --- and --

Back 93

atria

ventricles

so they have separate beats: heart block

Front 94

bb will cause ---glycemia in type 1 dm

Back 94

hypo

Front 95

bb will cause ---glycemia in type 2 dm

Back 95

hyper

Front 96

how will bb cause hypoglycemia in type 1

Back 96

bb prevent glycogenolysis which will prolong hypoglycemia and mask symptoms

Front 97

how will bb cause hyperglycemia in type 2

Back 97

decrease insulin and increase glucose

wil also prolong hypoglycemia and mask symptoms

Front 98

which bb increase insulin sensitivity in type 2 dm

Back 98

3rd gen

Front 99

because bb block b2 receptors in bl vessels what can happen

Back 99

cold extremities (raynaud's)

skeletal muscle fatigue

pad (intermittent claudication)

Front 100

how do you get skeletal muscle fatigue w/ bb

Back 100

due to contraction there's a block on O2 and glucose

Front 101

sudden stop of bbs you can have

Back 101

sudden withdrawal syndrome

Front 102

sudden withdrawal syndrome can lead to

Back 102

acute angina

mi

marked increase in bp

Front 103

blockade of beta can lead to --- of receptors

Back 103

upregulaation
so wil abrupt withdrawal of bb you have too many beta: increased bp, hr, workload

Front 104

t/f

you slowly withdrawal bb

Back 104

t

Front 105

due to lipid soluabilty of bb a pt can have ----

Back 105

depression

nightmares

vivid dreams

hallucinations

fatigue

Front 106

t/f

fatigue due to central actions

Back 106

f

central and cv actions

Front 107

bb may increase ldl, --- and decrease ---

Back 107

increase LDL and TG

decrease HDL

Front 108

which beta's improve lipid profile slightly

Back 108

3rd generation

slighly

Front 109

if you're borderline depressed --- can lead to depression

Back 109

bb

Front 110

drug interactions w/ bb

Back 110

ccb

clonidine

Front 111

which two meds should you not abruptly stop

Back 111

bb

clonidine

Front 112

what drug interaction w/ ccb

Back 112

synergictic effects:

decrease bp, hr, contractility (both thru av node)

Front 113

both bb and clonidine will --- bp

Back 113

decrease