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59 Cards in this Set
- Front
- Back
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ahluist classified receptors based on order of --- in tissues
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potency
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what are the two receptors he classified
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A
B |
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what the potency order of alpha receptors
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1. Epi
2. NE 3. Iso |
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the potency order of beta receptors?
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1. Iso
2. Epi 3. NE |
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Lands proposed --- and --- receptors
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B1
B2 |
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which B works in the heart?
smooth muscle? |
B1
B2 |
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langer proposed which two receptors?
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A1
A2 |
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which A is postsyn and pre?
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Postsyn: A1
Presyn: A2 |
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which A is a autoreceptor
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A2
decreases NE |
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arch discovered the -- receptor
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B3
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what was significant of creese's discovery
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there are A1 subtypes
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what are the A subtypes
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A1a
A1b A1d |
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which A1 subtype is a variant of A1a
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A1c
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byland's discovered
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A2 subtypes
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what are the A2 subtypes
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A2a
A2b A2c |
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which variant is a subtype of A2a
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A2d
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A1 is a G- coupled receptor
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q
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A2 is a G- coupled receptor
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i
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B is a G- coupled receptor
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s
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A1 on Gq will increase --- and ----
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IP3
DAG |
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A2 on Gi will decrease/increase cAMP and increase/decrease K channels
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decrease
increase |
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B on Gs increases/decreases cAMP
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increases
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where can you find a1A receptors
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heart
liver cerebellum cerebral cortex prostate lung vas deferens |
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where can you find a1B receptors
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kidney
spleen aorta lung cerebral cortex vascular smooth muscle |
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where can you find a1D recetpors
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aorta
cerebral cortex prostate hippocampus |
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where can you find a2A receptors
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platelet
cerebral cortex spinal cord locus ceruleus |
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where can you find a2B receptors
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liver
kidney |
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where can you find a2C receptors
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cerebral cortex
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g coupled receptors are a superfamily of ---- --- receptors
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cell surface
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how many members of the superfamily
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2000
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what do g coupled receptors activate
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2nd messengers
ion channels |
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what differences allow different responses
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structural differences
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how many aa on the g coupled receptros
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400-600
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where's cooh and nh2 on the g coupled
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nh2: outside
cooh: inside |
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how many membrances on the g coupled recept.
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7
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how many extracellular loops on the g coupled
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3
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how many intracellular on the g coupled
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3
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g coupled receptors have sites for ------ dependent phosphorylation
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protein
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g coupled receptors have sites for protein dependent ------
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phosphorylation
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some critical residue for EPI binding
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TM3
TM5 TM6 |
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what does TM3 bind to
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aspartate
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what does TM5 bind to
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serine
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what does TM6 bind to
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phenylalanine
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t/f
epi has the most effects on B3 |
f
no much effects ISO=NE>>>>> EPI |
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t/f
receptor subtype is absolute |
f
not absolute |
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t/f
receptor is dose dependent |
t
ex: DA acts on DA receptors at low doses, but at higher doses on a1, a2, b1, b2 |
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a1 agonist will ----- bp and works as a nasal ------
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elevate bp
nasal decongestant |
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a1 antagonist is a ----
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antihypertensive
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t/f
a2 agonist has many uses |
f
limited uses |
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b1 agonist will facilitate --- fx
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cardiac
elevate CO, HR, contractility |
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b1 antagonist are anti ----- and anti----
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antihypertensives
antiangina |
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b2 agonist relax ---- ----- muscle
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bronchial smooth
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uses of b2 antagonist
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not used therapeutically
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what's terbutaline selective for
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b2
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what's dobutamine selective for
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b1
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what's phenlyephrine selective for
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a1
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what's isoproterenol selective for
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b1
b2 |
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what's epi selective for
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a1
a2 b1 b2 |
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sometimes the there's therapeutic effect on one receptor and --- on another
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side effects
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