Use LEFT and RIGHT arrow keys to navigate between flashcards;
Use UP and DOWN arrow keys to flip the card;
H to show hint;
A reads text to speech;
29 Cards in this Set
- Front
- Back
Signs of polyneuropathy |
1. sensory: pain/temp (if small unmyelinated), v/p (if large myelinated)
2. motor: distal muscle atrophy (intrinsic hand muscles & digitorum brevis in feet)
3. ABSENT ANKLE JERKS (normal in old person)
4. autonomic: ORTHO HYPO!!!! |
|
3 types of polyneuropathies |
1. symmetrical generalized: "stocking glove" 2. multifocal: assymetrical (usually vasculitis) 3. focal mononeuropathy |
|
focal mononeuropathies |
-usually from traumatic injuries/entrapment -focal loss of myelin: CONDUCTION BLOCK!!! -good prognosis, Schwann cells replace myelin |
|
Diabetic neuropathy |
symmetric generalized |
|
severe burning pain, symmetric neuropathy |
EtOH |
|
B12 deficiency |
degeneration in spinal cord white matter pathways (the posterior columns and the corticospinal tracts). |
|
B6 deficiency |
-often from EtOH -DORSAL GANG -loss of V/P & gait ataxia!!! |
|
hypothyroid neuropathy can also have what? |
CARPAL TUNNEL |
|
hypothyroid neuropathy |
mucopolysaccharides and edema within the nerve connective tissue and in the tendon sheaths |
|
HYPERthyroid neuropathy |
subacute leg weakness and loss of reflexes |
|
Vincristine neuropathy |
inhibits microtubule polymerization and interferes with axonal transport |
|
begin with stocking-glove tingling, but eventually with profound distal weakness especially foot drop |
Vincristine |
|
cis-platin |
mosly V/P!! with lancinating pain |
|
Paclitaxel |
ovarian cancer drug that causes neuropathy |
|
antiretroviral drug neuropathy |
mostly a PAINFUL SMALL fiber neuropathy |
|
Ethambutol |
OPTIC neuropathy |
|
encephalopathy, GI Sx, RADIA**** neuropathy |
Pb toxicity!!! |
|
where is arsenic found? |
well water |
|
arsenic is similar to GBS |
but arsenic causes AXON loss, while GBS is demyelinating |
|
high ANCA and polyneuropathy |
ChurgStrauss & Wegeners |
|
patient gets URI or Campy, but antibodies directed against the INFECTION, actually attack PERIPHERAL NERVE MYELIN |
GBS |
|
GBS time frame |
<3 weeks!!!! |
|
most common CN involved in GBS |
7th!!! (often with b/l facial weakness) |
|
NO REFLEXES IN GBS |
s |
|
EMG for GBS |
CONDUCTION BLOCK! |
|
patient is AREFLEXIC, loss of V/P (from myelin), progressive ascending paralysis for a long time |
chronic inflammatory demyelinating polyradiculopathy |
|
charcot marie tooth (AD!!!) |
distal motor peripheral nerves are affected more than the sensory nerves and patients often present with a very slow and progressive bilateral foot drop and with atrophy below the knees. |
|
atrophy in feet of CMT patients |
very high arches and “hammer toes”. |
|
confusion, agitation, psychosis, ABDOMINAL PAIN, and PN |
porphyria |