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16 Cards in this Set

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Delerium definition

Organic brain syndrome SECONDARY to underlying cause

Delirium characteristics

-4 cardinal signs: acute/fluctuating, inattention, disorganized thinking,change in LOC


-Cognitive/perceptual disturbances: illusions and hallucinations


-Autonomic hyperactivity (increase in VS)


-Hypervigilance, labile mood, anger/agitation


-Can be life-threatening

Delerium mgmt

-Reorient, keep comfortable, safe


-Keep hemodynamic stability


-Keep hydrated


-Eventually AAOx3

Dementia definition

Gradual irreversible impairment in cognitive fx, decline in social and occupational fx, no change in LOC

Dementia risk factors

-Advanced age and family hx!


-Low SES and poor medical care

Dementia patho

-Theories: cerebral atrophy, neuritic plaques, tangles


-Neuronal death in hippocampus causes decrease in Ach


-4 A's: amnesia, aphasia, apraxia, agnosia


-Primary or secondary (ex: AIDS)

Dementia dx

-PET, CT, MRI, decrease in brain weight


-Only confirmed after autopsy

Dementia pharm: goals

-Improve sx and reverse cognitive decline (ideally)


-Actually to slow memory loss

Dementia pharm: Memantine

-Neuronal receptor blockerr


-NMDA antagonist


-Moderate-severe AD


-Regulates glutamate


-Better tolerated than cholinesterase inhibitors

Dementia pharm: Cholinesterase inhibitors

-For mild to moderate, except aricept


-Do not delay disease progression


-Improvements modest and short


-Start low, go slow!


-AE: bronchoconstriction (COPD/asthma)


-Avoid antihistamines, TCAs, conventional antipschotics

Dementia pharm: Aricept

-1x dosing, extended release


-Less peripheral AE


-FOR SEVERE AD


-Don't discontinue abruptly

Dementia: initial sx

Short term memory loss, language problems, disorientation, decrease in judgment, decrease in abstract thinking, changes in mood and personality, misplacing things

Dementia: Progressive sx

Dysphasia (inability to communicate), apraxia (loss of motor coordination), visual agnosia (can't recognize things), dysgraphia, wandering

Dementia dx

Mini mental status exam, H&P, imaging is not dx, just shows progression

Dementia: late sx

Long term memory loss, unable to communicate, incontinence, no ADLs

Communication strategies with dementia

Identify yourself, maintain face-to-face, encourage reminiscing, talk about familiar things, be 1-2 arms lengths, use visuals, engage in activities