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12 Cards in this Set
- Front
- Back
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General Psychostimulant Effects
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euphoria and dysphoria
energy/ hyperactivity insomnia anger anorexcia increased self esteem |
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Mechanism of Cocaine Action
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Inhibition of DA, NE, 5-HT reuptake
(effects depend on current rate of transmitter release) |
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Stimulant Effects on Nucleus Accumbens
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DA dependent
increase in locomotor activity Cocaine - not reinforcing Amphetamine - reinforcing (6-OHDA reduces reinforcement and locomotor) |
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Stimulant Effects on Striatum
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DA dependent increase in stereotyped behavior
(6-OHDA reduces stereotypy) |
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Cocaine effect on D1 knockout
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reducing locomotor stimulation
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BP 897
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DA receptor partial agonist: inhibits cocaine reinforcement
possible clinical addiction use |
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Cocaine Tolerance vs. Sensitization
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Tolerance: IV, continuous
Sensitization: Daily ip injection |
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Cocaine induced delusions
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Paranoia (paranoid schizophrenic symptoms)
Formication (sensation of small subcutaneous creepy crawlers) |
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Mechanism of Amphetamine Action
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Inhibition of DA, NE, 5-HT Reuptake
Direct release of DA, NE, 5-HT. (exchange through transporters) |
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Clinical uses of Amphetamine Derivatives
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ADHD: methylphenidate
Narcolepsy Previously, diet pills |
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Toxicity of high doses of amphetamines
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Neuronal damage over time (PET shows DA transporter densitiy decreases after heavy use)
Increased blood pressure can cause brain hemorrhage, etc |
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Toxicity of MDMA
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Long term decrease in 5-HT fiber density in neocortex (of monkeys)
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