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14 Cards in this Set
- Front
- Back
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Three Coagulopathies related to Pregnancy
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Idiopathic Thrombocytopenic Purpura (ITP)
Von Willebrand Disease Disseminated Intravascular Coagulation (DIC) |
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Clotting Factors
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Platelets
Fibrinogen Prothrombin Factors V and VII |
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Idiopathic Thrombocytopenic Purpura (ITP)
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Autoimmune disorder in which antiplatelet antibodies decrease the life span of the platelets
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ITP
Diagnostic finding: |
Thrombocytopenia
Capillary fragility Increased bleeding time |
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ITP
Complications: |
Severe hemorrhage after cesarean birth or from cervical or vaginal lacerations
Increased risk for postpartum uterine bleeding and vaginal hematomas |
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ITP
Treatment: |
Corticosteroids or IV immune globulin
Platelet transfusions Splenectomy if unresponsive to medical treatment |
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Von Willebrand Disease (VWD)
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Form of hemophilia
factor VIII deficiency and platelet dysfunction Most common hereditary bleeding disorder |
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VWD
Sign/Symptom |
Familial bleeding tendency
Previous bleeding episodes Prolonged bleeding time (most important) factor VIII deficiency Bleeding from mucous membranes |
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VWD
Risk for bleeding after birth |
Up to 4 weeks
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VWD
Treatment |
desmopressin IV, PO or nasally (promotes release of vW factor and factor VIII
Transfusion with plasma containing vW factor and factor VIII Concentrates of antihemophiliac factor (Humate-P, Alphanate) |
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Disseminated Intravascular Coagulation (DIC)
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Pathologic form of clotting that consumes large amounts of clotting factors
Causes widespread external and/or internal bleeding Small clots form in microcirculation |
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DIC
Causes |
Post partum hemorrhage
Abruption placentae Amniotic fluid embolism Dead fetus syndrome Severe preeclampsia Sepsis Saline abortion Acute fatty liver of pregnancy |
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DIC
Signs/Symptoms |
Unusual bleeding
Spontaneous bleeding from gums or nose Petechiae Tachycardia Diaphoresis |
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DIC
Treatment |
Correct underlying cause
Volume replacement, blood component therapy, oxygen, continual reassessment Resolution typically begins with birth of neonate |
