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14 Cards in this Set
- Front
- Back
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What activates platelets?
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Epinephrine, high physical stress, immune complexes, collagen, ADP, and thrombin
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Platelet activation results in:
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Change in shape, aggregation of platelets via GPIIB, adhesion of platelets via GPIB-vWF, and release of a VAST number of compounds
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List drugs that inhibit platelet activation.
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Aspirin- cox inhibitor
TXA2 Synthase inhibitor TXA2 R blocker- inhibits GPIIB-IIIa activation GPIIB-IIIa antagonists- blocks aggregation ADP inhibitors ADP R inhibitors |
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What is von WIllebrand disease?
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Deficiency in vWF. Causes easy bruising, acute nose hemorrhage, heavy menstrual bleeding, postoperative bleeding, bleeding from wounds, postpartum bleeding
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Describe the glycoprotein disorders.
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Bernard-Soulier syndrome- GP1b deficiency disrupts platelet adhesion to collagen
Glanzmann's thrombasthenia- deficiency in GPIIb disrupts platelet aggregation |
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What does vitamin K do?
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gamma-carboxylation of pro-coagulation factors: "1972CS" --> 10, 9, 7, 2, protein C and protein S
(carboxylation is necessary for calcium binding) |
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What does warfarin do?
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blocks gamma-carboxylation of glutamate residues in the 1972 factors. Found in rat poison.
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How does thrombin regulate the coagulation cascade?
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Thrombin activates factors 5, 8, and 11 while it binds to thrombomodulin (which then causes protein C/S activation and factor 5 & 8 degradation leading to coagulation inhibition)
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What does ATIII do?
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Anti-thrombin III irreversibly inactivates thrombin and is enhanced by heparin
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Describe hemophilia A & B
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A= factor 8 deficiency, X-linked, joint and muscle hemorrhage + bruising and prolonged bleeding
B= factor 9 deficiency, 1/10, prolonged coagulation time |
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Describe factor 13 deficiency
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Factor 13 is activated by thrombin to become active plasma transglutaminase. . Def result in neonatal umbilical cord bleeding, intracranial hemorrhage, soft tissue hematomas
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Describe vWF disease
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Most common (8000/million).
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Describe AT deficiency
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found in 2% of patients with venous thromboembolic disease. DVT and PE
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Describe aPTT/PTT and PT
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aPTT is for intrinsic = 12, 11, 9, 8 and common
PT is for extrinsic = TF, 7 and common |
