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34 Cards in this Set

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Platelets are derived from:
megakaryocytes
The lifespan of a platelet is approximately:
10 days
Do platelets contain a nucleus?
NO
Platelets are derived from
Megakaryoctyes
Platelets are activated by
ADP, Epinephrine, Collagen, Thrombin, Immune complexes, and high physical stress
The three roles of platelets are:
1. Activation (Change shape)
2. Aggregation
3. Adhesion to vessel wall
vWF is responsible for anchoring:
Platelets to the subendothelial collagen
Phospholipase A2
is responsible for cleaving a phospholipid and releasing arachidonic acid.
Arachidonic acid
is used to make thrombaxane (TXA2)
TXA2
is a vasoconstrictor
What are the six sites of inhibiting platelet activation?
1. Cyclooxygenase activity
2. Thromboxane synthetase
3. Thromboxane receptor
4. GPII antagonists
5. ADP inhibitors
6. ADP receptor inhibitor
von Willebrand disease
A deficiency of vWF
Bernard Soulier syndrome
A deficiency of GP1b-IX
Thrombocytopenia
Low Platelet count
Activation of factor VII requires:
factor III (Tissue factor)
Activation of factor XI
Requires factor XII
Activation of factor IX requires:
factor XI
Activation of factor II
Requires factor X and factor V
Factor XIII is:
the only non-serine protease enzyme. Factor XIII is actually a transglutaminase enzyme.
Fibrin breakdown requires:
Plasmin
Protein C (APC):
inhibits coagulation through the protein degradation of coagulation factor VIII and factor V
Hemophilia A
Deficiency in factor VIII
Hemophilia B
Deficiency in factor IX
The most common bleeding disorder is:
vWF disease
PGI2 is responsible for:
inhibiting coagulation by inducing vasodialation and is produced by endothelial cells.
What are the Vitamin K requiring clotting factors?
Factor II, X, IX, and VII as well as protien C/S.
hint: 1972
Warfarin
Inhibits Vitamin K Epoxide Reductase thus reducing the activation of coagulation factor II, X, IX, and VII.
Antithrombin III
Inhibits the activity of factor II or thrombin
Heparin
Induces antithrombin III's activity which inhibits thrombin's activity.
Prothrombin time measures
the extrinsic pathway & the common pathway
Activated partial thromboplastin time measures
the intrinsic pathway and the common pathway
Endothelial cells inhibit coagulation by:
producing PGI2, nitric oxide and inducing APC.
Endothelial cells block platelet binding by being:
negatively charged.
The D-dimer test will measure the:
breakdown of fibrin.