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34 Cards in this Set
- Front
- Back
- 3rd side (hint)
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Platelets are derived from:
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megakaryocytes
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The lifespan of a platelet is approximately:
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10 days
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Do platelets contain a nucleus?
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NO
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Platelets are derived from
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Megakaryoctyes
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Platelets are activated by
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ADP, Epinephrine, Collagen, Thrombin, Immune complexes, and high physical stress
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The three roles of platelets are:
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1. Activation (Change shape)
2. Aggregation 3. Adhesion to vessel wall |
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vWF is responsible for anchoring:
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Platelets to the subendothelial collagen
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Phospholipase A2
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is responsible for cleaving a phospholipid and releasing arachidonic acid.
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Arachidonic acid
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is used to make thrombaxane (TXA2)
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TXA2
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is a vasoconstrictor
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What are the six sites of inhibiting platelet activation?
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1. Cyclooxygenase activity
2. Thromboxane synthetase 3. Thromboxane receptor 4. GPII antagonists 5. ADP inhibitors 6. ADP receptor inhibitor |
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von Willebrand disease
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A deficiency of vWF
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Bernard Soulier syndrome
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A deficiency of GP1b-IX
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Thrombocytopenia
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Low Platelet count
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Activation of factor VII requires:
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factor III (Tissue factor)
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Activation of factor XI
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Requires factor XII
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Activation of factor IX requires:
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factor XI
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Activation of factor II
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Requires factor X and factor V
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Factor XIII is:
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the only non-serine protease enzyme. Factor XIII is actually a transglutaminase enzyme.
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Fibrin breakdown requires:
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Plasmin
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Protein C (APC):
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inhibits coagulation through the protein degradation of coagulation factor VIII and factor V
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Hemophilia A
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Deficiency in factor VIII
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Hemophilia B
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Deficiency in factor IX
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The most common bleeding disorder is:
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vWF disease
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PGI2 is responsible for:
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inhibiting coagulation by inducing vasodialation and is produced by endothelial cells.
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What are the Vitamin K requiring clotting factors?
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Factor II, X, IX, and VII as well as protien C/S.
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hint: 1972
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Warfarin
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Inhibits Vitamin K Epoxide Reductase thus reducing the activation of coagulation factor II, X, IX, and VII.
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Antithrombin III
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Inhibits the activity of factor II or thrombin
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Heparin
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Induces antithrombin III's activity which inhibits thrombin's activity.
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Prothrombin time measures
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the extrinsic pathway & the common pathway
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Activated partial thromboplastin time measures
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the intrinsic pathway and the common pathway
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Endothelial cells inhibit coagulation by:
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producing PGI2, nitric oxide and inducing APC.
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Endothelial cells block platelet binding by being:
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negatively charged.
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The D-dimer test will measure the:
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breakdown of fibrin.
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