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24 Cards in this Set
- Front
- Back
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What is found in the alpha granules of platelets?
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Fibrinogen
Fibrinectin VWF Thrombospondin Vitronectin |
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What is found in the dense bodies?
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ADP
ATP 5HT Ca |
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Steps of primary hemostasis
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Injured BV has exposed collagen
VWF binds collagen GPIb of platelet binds to VWF, causing conformational change in IIb/IIIA IIb/IIIA is now able to bind fibrinogen Platelets express receptors for factors V and VIII; extend pseudopods |
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What role does TXA2 play in coagulation and how does it work?
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TXA2 causes platelet aggregation and vasocontriction.
It decreases the level of cAMP, which causes an increase in Ca, which promotes platelet aggregation. |
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How does PGI2 work in coagulation? Where does it come from?
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Opposes the action of TXA2 by increasing the levels of cAMP, which decreases the levels of Ca. This inhibits platelet aggregation.
It is released by vascular endothelial cells. |
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What role does ADP play in coagulation?
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Causes platelets to swell and adhere to each other. It then caauses them to release TXA2 and more ADP in a positive feedback mechanism.
The clot formed is large enough to fill the injured area. |
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What is the tenase reaction?
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The reaction that causes the formation of Xa (IXa + VIIIa + X) -> Xa
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What does factor XIII do?
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Provides clot strength and normal wound healing.
Without it, clots dissolve more quickly |
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What does ATIII bind to?
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Heparan sulfate
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What does AT III inactivate?
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IX, X, XI, II
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What do proteins C and S inactivate?
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Va, VIIIa
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What does TFPI do?
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Inactivates VIIa-TF complexes
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What does heparin do?
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Enhances the activity of ATIII (inactivates Ix, X, XI, II)
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What does warfarin do?
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Binds vitamin K, so II, VII, X, XI, protein C and S are all inhibited
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What does thrombomodulin do?
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Causes the activation of protein C
Also inactivates all the other serine proteases in coagulation |
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What does tPA do?
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Converts plasmingen to plasmin, which then breaks up the clot and releases FSP (D-dimer)
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What does urokinase do?
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converts plasminogen -> plasmin, forms FSP (d-dimer)
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What releases tPA and urokinase?
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Endothelium
Fibrin |
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What does PAI-I do?
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down-regulates plasmin
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What is alpha-2-anti-plasmin?
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Inhibits fibrinolysis, by collecting free plasmin `
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IL-11
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Allows for increasing the number of circulating platelets
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C-MPL
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TPO receptor on platelets
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Treatments for VWD
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DDAVP
Intermdiate Purity Factor |
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What is Intermediate Purity Factor
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Combination of VWF and factor VIII; used to treat VWD
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