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10 Cards in this Set
- Front
- Back
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What is coagulation instrumentation based on?
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detection of an endpoint in the coag cascade when a clot forms.
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When are the 2 most common times you would use coag?
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1. To monitor anticoag therapy
2. before a surgical procedure |
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what are 2 common coag tests?
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PT: prothrombin time
APTT: actvtd ptl thromboplastin time also Factor assays |
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what is PT?
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the time it takes for a clot to form.
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What are 3 ways to measure coagulation?
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1. Manual
2. Mechanical 3. Optical |
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What is the manual method that we'll use next year called?
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Fibrometer
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What's the principle of the fibrinometer?
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1. Automatic pipetter shoots sample into cup, time starts.
2. Heater starts and 1 probe agitates. 1 probe stationary. 3. When clot forms, agitation stops; current flows; time stops. Endpoint detected! |
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What's an advantage/disadvantage of the mechanical method?
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-More precise btwn techs
-More cumbersome/frustrating method. |
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What are some different photometric coag methods?
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1. Light scatter optical
2. Turbidometric 3. Viscosity 4. Absorbance /or fluorescence. |
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What's a chromogenic assay based on?
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the fact that a chromophore when bound to pna doesn't shine, but when a coag factor cleaves it, it does shine. allows for factor assays.
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