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12 Cards in this Set
- Front
- Back
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For diagnosing bleeding disorders, what are the:
-Screen tests? -Confirmation tests? |
Screen: PT/PTT/BT/Plt count
Confirm: plt aggregation, factor assay |
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What generalized systemic defects can cause prolonged pt/ptts?
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-Liver disease
-Renal disease -Chronic cancer, etc. |
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How can bleeding symptoms differentiate Platelet vs. Coag factor deficiencies?
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Petichiae = PLATELETS, not coag factor.
-Also has spontaneous mucous membrane bleeding. |
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What's more common; acquired or hereditary coagulopathies?
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Acquired.
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What causes acquired coagulopathies?
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Aspirin, drugs, autoimmune disease, etc.
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What bleeding disorders are sex-linked recessive?
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-Hemophilia A/B
-Wiskott-Aldrich |
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How can the PT/PTT diff. btwn platelet/vasc disorders and Coagulation disorders?
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Platelet/vascular: PT/PTT are NORMAL
Coag: abnormal - prolonged |
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How does the BT differentiate them?
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BT is elevated in Plt/vasc, not in Coag factor deficiency.
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What 3 tests are used to diagnose platelet diseases?
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-Platelet aggregation
-Electrophoresis -Genetic studies |
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For coagulation defects:
-What are the screens? -What are the diagnostic tests? |
Screens: PT/PTT
Confirm: Electrophoresis, factor assays, genetic studies. |
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What type of abnormality will show HEMARTHROSES?
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Coag defects; not platelet.
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How does NORMAL PLASMA correct a prolonged PT/PTT?
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-Replaces 50% of all factors!
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