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30 Cards in this Set
- Front
- Back
Factor I
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Fibrinogen
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Factor II
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Prothrombin
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Factor III
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Tissue thromboplastin (Tissue Factor)
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Factor IV
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Ionized Calcium
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Factor V
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Labile factor
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Factor VI
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Doesn't exist!
|
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Factor VII
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Stabile factor
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Factor VIII
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-Anti-hemophiliac factor AHF
-VIII:C (oagulant portion) |
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Factor IX
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-Chrismas factor
-AHFb |
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Factor X
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Stuart-Prower factor
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Factor XI
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PTA --> plasma thromboplastin antecedent
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Factor XII
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Hageman factor
-contact factor |
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Factor XIII
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Fibrin-stabilizing factor
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Fitzgerald factor
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HMWKininogen
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Fletcher factor
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prekallikrein
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Which factor is a Substrate factor?
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Fibrinogen
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Which factor is a Cofactor?
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5-Labile factor
8-Factor VIII:C |
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Which factors are Enzymes?
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Many:
IIa, VIIa, IXa, Xa, XIa, XIIa, prekallikrein |
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Which factors are serine proteases?
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Any of the enzymes that have been activated.
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Which factor is a transaminase?
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Factor XIII
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What are the 2 ways to classify coagulation factors?
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1. By hemostatic function (above)
2. By physical properties |
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What are the 3 groups of factors based on phys. property?
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1. Contact proteins
2. Prothrombin proteins 3. Fibrinogen/thrombin sensitive proteins. |
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What 4 factors are Contact proteins?
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1. Prekallikrein
2. HMWK 3. Fx XII 4. Fx XI |
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What types of hemostasis problems assoc. w/ Deficient
-F XI -Hageman/Fletcher |
Factor XI = mild bleeding
Factors XII/Prekallikrein = thrombosis |
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What is in the prothrombin group?
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Low-molecular wght proteins:
II, VII, IX, X 2, 7, 9, 10 |
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What's another name for the prothrombin group?
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Vit-K dependent group.
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What makes the Vit-K group unique?
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Gamma-carboxyglutamic acid - necessary for binding to platelets and Ca2+ binding.
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What acts as an antagonist to vitamin K?
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Warfarin - Coumadin.
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Why is the extrinsic pathway called extrinsic?
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B/c Tissue Factor (its phospholipid activates cascade) isnt normally in circulation.
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Where are the necess phospho-lipids for intrinsic pathway?
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In platelet membranes.
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