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4 Cards in this Set
- Front
- Back
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CNS stimulants that release catecholamines (mostly DA)
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1. amphetamine (Adderal)
2. dextro-amphetamine (Dexedrine) 3. methamphetamins (Desoxyn) 4. methylphenidate (Ritalin SR, Concerta, Metadate) 5. pemoline (Cylert)- long acting (caution due to hepatic failure) 6. ephedrine (Ephedra and others- also an alpha and beta agonist 7. atomexitine (Strettera) NE reuptake blocker |
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CNS stimulants that block the reuptake of catecholamines and serotonin
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1. cocaine
2. mazindol (Sanorex) 3. sibutramine (Meridia)- h as 2 active metabolites with relatively long half lives 4. modafinil (Provigil); although there is a strong disclaimer about its CNS stimulant properties |
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methylxanthines
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adenosine receptor antags; not truly considered "psychomotor" stimulants, but have distinct stimulant effects
1. caffeine-short acting 2. theophylline- long acting, used for nighttime asthma (also blocks phosphodiesterase) |
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Therapeutic indications for CNS stimulants
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1. obesity- must consider issue of differential tolerance and weigh positive and negative aspects of chronic administration
2. ADHD- effects are not paradoxical as all CNS stimulants, produce a rate-dependent effect 3. narcolepsy- probably a specific effect on the reticular activating system in the brain (can give same dose for years and will not be tolerant) |
