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13 Cards in this Set
- Front
- Back
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Xanthines at low doses
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adenosine receptor antagonists
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Xanthines at high doses
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PDE inhibitors
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Theophylline therapeutic index
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very narrow
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Tolerance to CNS stimulants (theophylline and caffeine)
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develops to CNS stim, but not effects on airway
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physical dependence due to CNS stimulants (caffeine and theophylline)
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withdrawal may cause headache, lethargy, and irritability
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sympathomimetic amines
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amphetamine
dextroamphetamine methyphenidate |
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Amphetamine dependence
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great psychological dependence
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Physical dependence associated with amphetamine abuse
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withdrawal of drug is not marked by abstinence syndrome; will have large cravings for drug though
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Abuse of amphetamines
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neurotoxicity marked by loss of 5HT neurons
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acute amphetamine toxicity mainly due to
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cardiovascular actions
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cocaine MOA
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local anesthetic and inhibition of neuronal reuptake of NE, DA, and serotonin
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Cocaine withdrawal
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few phyical symptoms; craving for drug
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amphetamine MOA
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release of NE and DA (possibly serotonin)
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