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22 Cards in this Set
- Front
- Back
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Ionotropic receptors
excitatory: inhibitory: |
AMPA, kainate NMDA glutamate
GABA |
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Metabotropic
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coupled with g protein
glutamate receptors GABA B alpha and beta adreneergic receptor |
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Glutamate
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Excitatory
Na dependent Type I G protein Type II inhibit cAMP |
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NMDA
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ionotropic
excitotoxity intraceullar ca glutamate excito learning, memory, epieptic seizure |
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GABA
A B |
inhibitory, synthesized by GAD and required vitb6
A agonists: benzodiazepine, GABA, barbiturate, steriod, picrotoxin Antagonist:bicuculline, pentylenetratrazol B Presynaptic: block Ca: Baclofen Post: open K |
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Serotonin 5HT
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depression
tryptophan fluoxetine: block reuptake SSRI MAO degrade LSD reduce amt |
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Acetylcholine
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excitatory
Nicotinic: muscarinic: |
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Neuropeptides
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Neuropeptide Y
enkephalin endorphin |
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Cocaine
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indirectly presyn action
blocks reuptake of DA short half life tolerance to euphoric effects leads to paranoia toxic effect: cardiovascular, seizures Withdrawl: fatigue, depression, craving, |
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Amphetamine
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release DA from vesicular stores
paranoid psychotic, auditory hallucinations facilitate weight loss |
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fenfluramine
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facilitate weight loss
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phenylpropanolamne
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facilitate weight loss
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methamphetamine
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Amphetamine
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phenmetrazine
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Amphetamine
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diethylproprion
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Amphetamine
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Psychedelics
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LSD
PCP partial agonist throughtout the brain |
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Indoleamines
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LSD DMT psilocybin
partial agonist throughtout the brain |
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Phenethylamine
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mescarline, DOM, MDMA (neurotoxic)
partial agonist throughtout the brain |
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PCP
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noncompetitive blockers of NMDA
anesthetic agitated psychoic state |
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detamine
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noncompetitive blockers of NMDA
anesthetic agitated psychoic state |
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dizocipline
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noncompetitive blockers of NMDA
anesthetic agitated psychoic state |
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Buspirone
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partial agonist
anxiety, depression, psychoiatic disorder safer |
