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35 Cards in this Set

  • Front
  • Back
Structure of amphetamines
like catecholamines but more lipid soluble for faster BBB penetrance
Absorption, Distribution, Metabolism for amphetamines
Orals absorbed
Long acting
Degraded in the liver with partial kidney excretion
How to increase rate of elimination of amphetamines
Acidify the urine with NH4Cl
Amphetamines mechanism of action
releases vesicles of NE, DA and 5-HT
Rebound effects of amphetamines
Depression, hypersomnia
Tx of high dose amphetamines
nitroprusside or alpha blocker for BP and sedatives
New alternative to amphetamines for treatment of hypersomnia
Modafinil
Modafinil
alternative to amphets for tx of hypersomnia
Orlistat
Pancreatice lipase inhibitor for tx of obesity
Pancreatic lipase inhibitor
Orlistat
Sibutramine
NE & SRI

enhance satiety and themogenesis

Side Effect restrict tx to BMI>30
Methylphenidate
Ritalin
Tx for ADHD
related to amphetamines
Cocaine
DA, NE and 5HT reuptake inhibitor
Treat cocaine psychosis
neuroepileptics or diazepam for psychosis and convulsions.

Does not treat peripheral symptoms like dysrhythmia
Three main CNS effects of theophylline and caffeine
1) increased alterness
2) respiratory stimulation
3) convulsion at high dose
main mechanism of action of theophylline at normal doses
adenosine inhibitor
Uses for methylxanthines
primary apnea of prematurity
asthma
GI and cardiac effects of nicotine
Increased GI motility
tachycardia
BP elevation
Type of dependence nictonine produces
Phsychological

Physical is very mild (increased apeptite)
How to treat nicotine overdose
gastric lavage and activated charcoal
Half life of nicotine
2 hours
Serotonin and NE regulate which factor?
Brain Derived Neurotrophic Factor (BDNF)

A DNA modulated increase, which accounts for delay in efficacy.
TCA's
amitriptyline nortriptyline
impiramine despipramine
Side Effects at normal doses for TCA's
sedation
insomnia
fine tremor
Side Effects at high doses of TCA in those susceptible
Mania (bipolar)
Seizure (epileptics)
Toxic psychosis at very high dose
Peripheral side effects of TCA's
like antipsychotics

Orthostasis
Quinidine like cardiac effects
Anti-ACh effects
Weight gain
Anti-depressent dosing recommendations
Lethal at 10-20 times daily dose

Only prescribe 1 week at a time
Alternative uses for TCA's
chronic pain
REM sleep supression
OCD (clomipramine)
Clomipramine
TCA used for OCD
Used for OCD
Clomipramine
Prototype SSRI
Fluoxetine
SSRI's
Fluoxetine
Sertraline
Fluvoxamine
Paroxetine
Diference between SSRI's and TCA's
no alpha, H or muscarinic activity, so none of the common side effects with TCA's
Common side effects of SSRI's
nausea, insomina and sexual side effects

Serotonin syndrome
Buproprion
Stimulant, atypical AD

Helps to quit smoking

High risk of seizure