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20 Cards in this Set
- Front
- Back
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Strychnine
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Analeptic.
MoA: Blocks Glycine receptor. Effects: Skeletal muscle spasm, convulsions, Inc respiration. |
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Methylphenidate
- Action - Uses - Adv Effects |
Amphetamine Analog.
MoA: Central & motor stimulation Uses: ADHD Chronic Use/ Abuse = paranoia, dependence. |
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Amphatamine
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Central & Motor Stimulant
- narcolepsy, ADHD, appetite reduction Ch use / Abuse = paranoia, dependency |
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Modafinil
- Action - Uses - Adv Effects |
Amphetamine Analog.
MoA: cental & motor stimulation Uses: Narcolepsy Ch use/Abuse = paranoia, dependence. |
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Sibutramine
- Actions - Uses - Adv Effects |
Serotonin agonist.
NE reuptake antagonist. Treatment of obesity (feeling of fullness - pharmacologic anorexia) Adv Eff = sleep disturbance, diarrhea, drug interactions |
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Mechanism of Action of Methylxanthines
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Caffeine & Theophylline (theobromine)
MoA: - Blocks adenosine receptor = Inc cAMP. - Inhibit cyclic nucleotide phosphodiesterase = Dec cAMP breakdown. |
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Uses of Caffeine
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Methylxanthine
Uses: CNS stimulation, **migraine headache,** apnea of prematurity, dysmenorrhea |
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Uses of Theophylline
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Methylxanthine
Uses: CNS stimulation Apnea of Prematurity **Asthma** **Biliary Colic** dysmenorrhea |
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Manifestations of Caffeine Toxicity
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Excitement
Tachycardia Convulsions |
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Manifestations of Methyxanthine withdrawl
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mild headache & lethargy.
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What drugs are Methylxanthines?
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Caffeine
Thiophylline Theobromine |
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What are effects of hallucinogens?
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Perceptual Distortions
Hallucinations Mydriasis, ataxia, Inc HR & BP, Inc muscle tone, hyperreflexic, N/V Magical thinking, paranoia, variable behavior changes |
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LSD
- Actions - Effects - Adv Effects |
MoA:
5HT2 (serotonin) & Indole analogues Effects: Vivid visual & auditory hallucinations Adv Eff: risky behavior. |
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Psilocybin
- Actions - Effects - Adv Effects |
MoA:
5HT2 (serotonin) & Indole analogues Effects: Vivid visual & auditory hallucinations Adv Eff: risky behavior. |
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Mescaline
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Hallucinogen: Epi/NE analog
Effects: hallucinations & CNS stimulation Significant Toxicity: Seizures, cardiac stim, etc. |
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Methylene Dioxymethamphetamine
(MDMA, ecstasy) |
Hallucinogen: Epi/NE analog
Effects: hallucinations & CNS stimulation Significant Toxicity: Seizures, cardiac stim, etc. |
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atropine, scopolamine, ditran, clidinium
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Anticholinergic Hallucintogens (delirants only at toxic doses.
(also tachycardia, hyperthermia, coma, death) |
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d9-Tetrahydrocannabinnol
(THC) |
mimics anandamide (endogenous) @ CB1 receptor.
Uses: Anti-emetic, Inc appetite, Dec intraocular pressure (refractory to alternatives), analgesia, antidepressant, sedation. Adverse Effects = tachycardia, red conjunctiva, euphoria, hallucinations, hypothermia, memory loss/suppression, impairment of judgment & motivation. |
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Phencyclidine (PCP)
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NMDA receptor antagonist
(sim to Ketamine) Dissociative Anesthetic Hallucinogenic Adv Eff: HTN, confusion, aggression |
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Effects of Caffeine & Theophylline.
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CNS stimulation (inc mental functioning &; wakefulness)
Respiratory Stimulation (Inc CO2 sensitivity at Resp Centers) Cardiac Stimulation (Inc HR, Q, contractility) Constriction of cerebral vessels. Dilation of cardiac & systemic vessels. Smooth muscle relaxation (bronchodilation, uterine relaxation) Diuresis |
