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32 Cards in this Set
- Front
- Back
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Glutamate |
NMDA receptor Agonist - major excitatory neurotransmitter - increase in Na+, K+ AND Ca2+ conductance |
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Morphine |
Mu Opioid Receptor (MOR) agonist - presynaptic inhibition of glutaminergic and GABAergic neurons - Opiate (natural derivative of opium) - used for treatment for moderate-severe pain - euphoria, analgesia and sleep - some have adverse reactions to it (sigma binding) - can be addictive |
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Heroin |
Mu Opioid Receptor (MOR) Agonist - presynaptic glu and GABA inhibition - Opiate (some heroin is found in opium) and synthetic opioid (heroin used on street made this way) - produces euphoria, analgesia and sleep - has varying levels of potency depending on source (switching sources fatal for Joplin) - recreational use > pain relief in rate of addict. |
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THC |
Cannabinoid receptor 1 agonist (CB1) - presynaptic inhibition of glu and GABA (prevents vesicle fusion) - glu effects = euphoria/dissoc. thinking/halluc. - GABA effects = relaxation/tranquility |
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Phenylcyclidine (PCP) |
NMDA receptor antagonist - inhibits Na+, K+, Ca2+ conductance
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Acetylcholine |
Cholinergic (M and N receptor) Agonist - important neurotransmitter in learning/memory |
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Donepezil |
Cholinergic Angonist |
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Benztropine
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Cholinergic Antagonist |
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GABA |
Major Inhibitory NT (GABA receptor agonist) |
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Diazepam |
Benzodiazepine - binds to GABA a |
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Phenobarbital
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Barbituate - binds to GABAa |
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Ethanol |
An Alcohol (Zero order kinetics) - binds to GABAa |
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Methanol |
An alcohol (Zero order kinetics) - binds to ethanol site on GABAa |
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Dopamine |
Common Neurotransmitter - involved in addiction and motor behaviours |
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L-DOPA |
Dopamine treatment (precursor of dopamine) |
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Amphetamine |
DA reuptake reversal |
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Cocaine |
DA reuptake inhibitor |
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Phenelzine |
MAO inhibitor |
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Selegiline |
MAO inhibitor |
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Ropinirole |
D2 agonist (D2 = inhibitory) |
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Norepinephrine |
Catecholamine (Dopamine-related NT)
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Tyramine |
MAO inhibitor - fermented foods |
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Imipramine |
Tricyclic Antidepressant (Block 5-HT and NE reuptake) |
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Serotonin |
Indolamine NT (related to catecholamines) |
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Fluoxetine |
Selective Serotonin Reuptake Inhibitor
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Lysergic diethyl acid (LSD) |
5-HT2A agonist |
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Olanzapine |
5-HT2a antagonist (and dopamine antagonist) |
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Haloperidol |
Dopamine antagonist and 5-HT2a antagonist |
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Lithium |
5-HT2a Receptor Indirect Inhibitor - Blocks IP3/DAG pathway |
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Buproprion |
Increases levels of Catecholamines * mechanism not understood * thought to block reuptake weakly and stimulate NE and DA secretion |
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Methadone |
MOR agonist - less addictive than heroin/morphine |
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Naloxone |
MOR antagonist
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