Cns Pharm

Front 1

which class of neurotransmitters have the fastest action?

Back 1

amino acids like GABA and glutamate are fast acting

Front 2

main side effect of SSRI?

Back 2

inhibition of sexual climax is main side effect

Front 3

During stress this chemical in the hippocampus decreases?

Back 3

BDNF decreases

Front 4

central cholinergic neurotransmission is mostly found where in the synapse?

Back 4

pre-synaptic is more likely location

Front 5

which muscarinic receptor is considered inhibitory?

Back 5

M2 receptor is considered inhibitory

Front 6

MAO inhibitors mainly target what neurotransmitters?

Back 6

Norepi and serotonin are primarily targeted

Front 7

antiepileptics primarily target this neurotransmitter?

Back 7

glutamate is primarily target

Front 8

glutamate derived from, storage, receptor, and termination?

Back 8

derived from glucose, glutamine, stored in synaptic vesicles, 4 different receptors and terminated by reuptake into nerve terminal and astrocytes

Front 9

GABA location, derivation, storage, receptors, and termination?

Back 9

only located in brain, derived from glutamate via glutamic acid decarboxylase, stored in synaptic vesicle, A and B receptor, and terminated by GABA transaminase

Front 10

dopamine termination?

Back 10

precursor to norepi terminated by reuptake and metabolism by MAOB and COMT

Front 11

three dopaminergic pathway?

Back 11

nigrostriatal (parkinson), mesolimbic/mesocortical (reward), tuberoinfundibular,

Front 12

schizophernia has which receptor increase?

Back 12

D2 receptor increased

Front 13

5-HT1 group receptors location and function?

Back 13

found in CNS, blood vessel, for constriction in large vessels and dialation in arterioles

Front 14

5-HT3 group receptor location?

Back 14

peripheral nervous system

Front 15

5-HT4 group receptor location?

Back 15

enteric nervous system

Front 16

varenicline MOA?

Back 16

helps quit smoking by acting as partial agonist to alpha4beta2 nicotinic receptor and as nicotine blockage from cigarette

Front 17

func. of amygdala?

Back 17

assessing experience is pleasurable or not

Front 18

main chemical in reward system that is involved in tolerance?

Back 18

CREB

Front 19

dinorphin func?

Back 19

protein that decreases dopamine activity in VTA

Front 20

deltaFosB func?

Back 20

resoponsible for activating genes that sensitizes nucleus accumbens causing a sense of craving

Front 21

location of chemo-receptor trigger zone?

Back 21

area postrema of NTS

Front 22

receptors located in the inner ear?

Back 22

H1 and M receptors (reason why D2 and 5-HT3 receptors don't work

Front 23

example of high emetogenic chemo.?

Back 23

cisplastin is one example

Front 24

5-HT released from what cells in stomach?

Back 24

Enterochromaffin cells release via Ca-dependent exocytosis

Front 25

5-HT3 receptor antagonists all end in?

Back 25

~setron

Front 26

MOA of delayed emesis?

Back 26

thought to work through activation of NK1 receptors activated by substance P

Front 27

substance P belongs to what family?

Back 27

tachykinin family also includes neurokinin A and B

Front 28

Which drug is an NK1 antagonist?

Back 28

aprepitant

Front 29

reason dexamethasone dosage has to be decreased with aprepitant?

Back 29

moderate inhibitor of CYP3A4

Front 30

aprepitant interactions?

Back 30

warfarin, dexamethosone, methylprednisolone, OCP

Front 31

drugs helpful in anticipatory emesis?

Back 31

anxiolytic drugs like benzodiazepenes are helpful

Front 32

which 5-HT3 antagonist has more pronounced QT interval?

Back 32

dolasetron has highest effect

Front 33

examples of D2 antagonists and which one crosses BBB?

Back 33

phenothiazine, butyrophenone metocloperamide (BBB) and domperidone are examples

Front 34

side effect of metocloperamide?

Back 34

since it crosses BBB, extrapyramidal effects can be seen

Front 35

examples of H1 antihistaminics and use?

Back 35

for motion sickness

Front 36

cannabinoid anti-emetic MOA?

Back 36

action on CB1 receptor in NTS and higher limbic and cortical regions

Front 37

time span of morning sickness

Back 37

after 4-7wks. last menstural cycle to 20wks. gestation

Front 38

dopamine released from where in parkinson's?

Back 38

pars compacta of substantia nigra

Front 39

which dopamine receptor is activating?

Back 39

D1 receptor is activator

Front 40

which globus pallidus involved in the indirect pathway?

Back 40

globus pallidus lateralis(externa) involved

Front 41

which dopamine agonist is best for young people? side effects?

Back 41

rotigotine transdermal patch with sodium metabisulfite (possible allergic rxn.) and aluminum (MRI contraind.)

Front 42

which drug acts on D3 receptor?

Back 42

pramipexole works on this receptor

Front 43

COMT inhibitors end in?

Back 43

~capone

Front 44

example of MAOBI?

Back 44

selegiline, slows down radical production

Front 45

advantage of rasagiline over selegiline?

Back 45

rasagiline not metabolized to amphetamine

Front 46

which COMT inhibitor is hepatotoxic?

Back 46

tolcapone has side effect

Front 47

4 MOA of amantadine?

Back 47

increase release, decrease uptake, anticholinergic property and NMDA receptor blocker

Front 48

short acting dopamine agonist?

Back 48

apomorphine

Front 49

which levels of sleep suppressed by BDZ?

Back 49

stage 4 and REM sleep suppressed

Front 50

muscle relaxant MOA of BDZ?

Back 50

increase GABA activation

Front 51

which BDZ good for panic and phobia disorders?

Back 51

alprazolam and clonazepam

Front 52

indications for buspirone?

Back 52

chronic anxiety tx. without sedative or dependency effects, slow onset

Front 53

memory impairment most likely occurs with which BDZ?

Back 53

triazolam is BDZ that most likely causes

Front 54

other uses of BDZ beside anti-anxiety?(6)

Back 54

alcohol withdrawal, insomnia, premenstrual dysphoric disorder, anti-convulsant, neuromuscular disorders, preanesthesia

Front 55

flumazenil effect on BDZ?

Back 55

BDZ antagonist?

Front 56

side effects of alprazolam?

Back 56

short duration, discontinuation, early relapse